FXYD2 and ATP1A1

Number of citations of the paper that reports this interaction (PMID 11832419)
9

Data Source:
HPRD (in vivo)

		FXYD2	ATP1A1
Gene Name		FXYD domain containing ion transport regulator 2	ATPase, Na+/K+ transporting, alpha 1 polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane T-tubule Vesicle Sarcolemma Melanosome Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Transporter Activity Ion Channel Activity Sodium:potassium-exchanging ATPase Activity	Sodium:potassium-exchanging ATPase Activity Protein Binding ATP Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Potassium Ion Binding Sodium Ion Binding ADP Binding Phosphatidylinositol 3-kinase Binding Chaperone Binding Steroid Hormone Binding
	Biological Process	Regulation Of Cell Growth Transport Potassium Ion Transport Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Cell Proliferation Transmembrane Transport	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Cellular Sodium Ion Homeostasis Regulation Of Blood Pressure Potassium Ion Import Dephosphorylation Cellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Ion Transmembrane Transport Sodium Ion Export From Cell Response To Drug Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Membrane Hyperpolarization Cellular Response To Mechanical Stimulus Cellular Response To Steroid Hormone Stimulus Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Glycoside
Pathways		Ion transport by P-type ATPases Ion channel transport	Ion transport by P-type ATPases Ion channel transport
Drugs		Cyclothiazide	Digoxin Acetyldigitoxin Hydroflumethiazide Ethacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Bepridil Potassium Aluminium Magnesium Digitoxin Almitrine
Diseases
GWAS
Protein-Protein Interactions		1 interactors: ATP1A1	14 interactors: A2M ADD1 CFL1 EGFR EZH2 FXYD1 FXYD2 FXYD7 HGS MAPK1 MAPK3 NDRG1 PRKCA TPT1
Entrez ID		486	476
HPRD ID		03487	01662
Ensembl ID		ENSG00000137731	ENSG00000163399
Uniprot IDs		P54710	P05023
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Glycoside Negative Regulation Of Glucocorticoid Biosynthetic Process Sodium Ion Export From Cell Sodium Ion Export Negative Regulation Of Steroid Hormone Biosynthetic Process Cellular Potassium Ion Homeostasis Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Hormone Biosynthetic Process Positive Regulation Of Striated Muscle Contraction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Glucocorticoid Metabolic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Sodium Ion Homeostasis Membrane Repolarization Relaxation Of Cardiac Muscle Cell Communication By Electrical Coupling Potassium Ion Homeostasis Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Heart Contraction Potassium Ion Import Relaxation Of Muscle Negative Regulation Of Steroid Metabolic Process Sodium Ion Homeostasis Regulation Of Hormone Biosynthetic Process Positive Regulation Of Heart Contraction Regulation Of The Force Of Heart Contraction Regulation Of Hormone Metabolic Process Membrane Hyperpolarization Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Lipid Biosynthetic Process Cardiac Conduction Cardiac Muscle Contraction Regulation Of Sodium Ion Transport Heart Contraction Regulation Of Steroid Biosynthetic Process Cellular Response To Mechanical Stimulus Regulation Of Cardiac Muscle Contraction Negative Regulation Of Lipid Metabolic Process Striated Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Regulation Of Steroid Metabolic Process Regulation Of Lipid Biosynthetic Process Regulation Of Muscle Contraction Regulation Of Heart Contraction Regulation Of Blood Pressure Cellular Response To Steroid Hormone Stimulus Potassium Ion Transmembrane Transport	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Activation Platelet Activation Regulation Of MAP Kinase Activity Response To Epidermal Growth Factor Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Regulation Of Intracellular Signal Transduction Regulation Of Golgi Inheritance Positive Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Blood Coagulation Regulation Of Kinase Activity Hemostasis Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of MAPK Cascade Response To Fibroblast Growth Factor Positive Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Activation Of MAPKK Activity Neurotrophin Signaling Pathway Regulation Of Golgi Organization Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Body Fluid Levels Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Chemotaxis Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stress Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport
Tagcloud ?		adaptations adjustments alpha1beta1 arystarkhova ascending atpase compensatory convoluted cotransporter dct generates hypoplasia na ncc nephron nkcc2 nonetheless permissive reabsorption s71 segment slc12a1 slc12a3 t53 thiazide thick tubule twofold	aldosterone betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption scnn1a scnn1b stepwise synergy transcriptomic
Tagcloud (Difference) ?		adaptations adjustments alpha1beta1 arystarkhova ascending atpase compensatory convoluted cotransporter dct generates hypoplasia na ncc nephron nkcc2 nonetheless permissive s71 segment slc12a1 slc12a3 t53 thiazide thick tubule twofold	aldosterone betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures scnn1a scnn1b stepwise synergy transcriptomic
Tagcloud (Intersection) ?		reabsorption