FXYD2

Description		FXYD domain containing ion transport regulator 2
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GO Annotations	Cellular Component	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Basolateral Plasma Membrane Extracellular Exosome
	Molecular Function	ATPase Activator Activity Protein Binding Sodium Channel Regulator Activity Protein-macromolecule Adaptor Activity Ion Channel Regulator Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Negative Regulation Of Cell Population Proliferation Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Cellular Hyperosmotic Salinity Response Inorganic Cation Transmembrane Transport Proton Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		Cyclothiazide Bisacodyl Thimerosal Tegoprazan
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: ATP1A1 ERGIC3 RRS1 SGTA SLC22A1 SLC22A2
Entrez ID		486
HPRD ID		03487
Ensembl ID		ENSG00000137731
Uniprot IDs		P54710
PDB IDs		2MKV 7E1Z 7E20 7E21
Enriched GO Terms of Interacting Partners?		Acetylcholine Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transmembrane Transporter Activity Catecholamine Uptake Dopamine Uptake Azole Transmembrane Transport Serotonin Transport Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Neurotransmitter Transmembrane Transporter Activity Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity Dopamine Transport Neurotransmitter Reuptake Xenobiotic Transmembrane Transporter Activity Monoamine Transport Neurotransmitter Uptake Basolateral Plasma Membrane Purine-containing Compound Transmembrane Transport Vitamin Transport Xenobiotic Transport Circulatory System Process Export Across Plasma Membrane Apical Plasma Membrane Basal Plasma Membrane Lateral Plasma Membrane Transport Across Blood-brain Barrier Organic Cation Transport Fatty Acid Transport
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