LCE3D and PCSK5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCE3D	PCSK5
Description		late cornified envelope 3D	proprotein convertase subtilisin/kexin type 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Golgi Membrane Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Trans-Golgi Network Endomembrane System Membrane
	Molecular Function	Protein Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Peptide Binding
	Biological Process	Epidermis Development Keratinization	Kidney Development Renin Secretion Into Blood Stream Signal Peptide Processing Proteolysis Cell-cell Signaling Heart Development Female Pregnancy Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Secretion By Cell Plasma Lipoprotein Particle Remodeling Limb Morphogenesis Peptide Biosynthetic Process Embryonic Digestive Tract Development Embryonic Skeletal System Development Cytokine Precursor Processing
Pathways		Formation of the cornified envelope	NGF processing Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Psoriasis ( 19169255 20953190 23143594 25854761)	A body shape index ( 34021172) Alzheimer's disease progression score ( 29860282) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Ankylosing spondylitis ( 30946743) Apolipoprotein B levels ( 32203549) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) Glucocorticoid-induced osteonecrosis ( 26265699) Glucose homeostasis traits ( 25524916) Height ( 20881960 31562340 28552196 23563607 25282103) Hip circumference adjusted for BMI ( 34021172) Hypotension and cognitive impairment ( 31362389) Inflammatory bowel disease ( 27569725) Intraocular pressure ( 31959993 29785010 30054594) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lead levels ( 26025379) Low density lipoprotein cholesterol levels ( 32154731) Male fertility ( 22633400) Metabolite levels (5-HIAA) ( 23319000) Pursuit maintenance gain ( 29064472) Response to fenofibrate (adiponectin levels) ( 23149075) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Systemic sclerosis ( 30247649) Takayasu arteritis ( 25604533) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Vascular brain injury ( 25188341) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172) Weight ( 34074324)
Interacting Genes		69 interacting genes: ADAMTSL4 ALPP CCN3 CHIC2 CYP21A2 CYSRT1 EFEMP1 EFEMP2 FBLN2 HOXA1 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2A LCE2B LCE2C LCE2D MACO1 MDFI NBPF19 NOTCH2NLA PCSK5 RGS17 RGS20 SDC3 SPRY1 SPRY3 SRPK1 SRPK2 TENM4 TGFB1 TRIM42 TSPAN4 VWC2 VWC2L	70 interacting genes: ADAMTSL4 AMH APPBP2 ATN1 C17orf50 C22orf39 CACNA1A CCDC33 CREB5 CYSRT1 DBF4B DOCK2 FAM86C1P FARS2 FRS3 GLRX3 GUCD1 HOXA1 HOXB9 INCA1 ITGA6 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-9 LCE1D LCE1F LCE2C LCE3A LCE3C LCE3D MDFI MEOX2 NBPF19 NOTCH2NLA NR1D2 NR4A3 NUFIP2 OTX1 PCSK6 PLSCR4 PMCH POU4F2 PTPRM REN SHFL SMCP SPRY1 SSC4D STK16 TEKT4 TLE5 TRAF4 TRIB3 TRIM42 TRIP13 USP54 VGLL3 ZNF547 ZNF655 ZNF837
Entrez ID		84648	5125
HPRD ID		17263	08985
Ensembl ID		ENSG00000163202	ENSG00000099139
Uniprot IDs		Q9BYE3	A0A669KA35 Q92824
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Cytosol Keratinization Protein Binding Extracellular Matrix Interstitial Matrix	Intermediate Filament Keratin Filament Epidermis Development Keratinization Identical Protein Binding Tissue Development Protein Binding
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