SYNPO and NDST1

		SYNPO	NDST1
Description		synaptopodin	N-deacetylase and N-sulfotransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Postsynaptic Density Actin Cytoskeleton Z Disc Cell Projection Dendritic Spine Perikaryon Organelle Synapse Anchoring Junction Spine Apparatus Glutamatergic Synapse	Golgi Membrane Golgi Apparatus Membrane Trans-Golgi Network Membrane
	Molecular Function	Actin Binding Protein Binding	Catalytic Activity Protein Binding Sulfotransferase Activity Heparan Sulfate N-sulfotransferase Activity Transferase Activity Hydrolase Activity Deacetylase Activity N-acetylglucosamine Deacetylase Activity Heparan Sulfate N-deacetylase Activity
	Biological Process	Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Stress Fiber Assembly Spine Apparatus Assembly	Polysaccharide Biosynthetic Process Cardiac Septum Development Inflammatory Response Heart Development Respiratory Gaseous Exchange By Respiratory System Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Heparan Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Heparin Proteoglycan Biosynthetic Process Forebrain Development Midbrain Development Aorta Development Positive Regulation Of MAPK Cascade Positive Regulation Of Smoothened Signaling Pathway Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis Coronary Vasculature Development
Pathways			HS-GAG biosynthesis
Drugs			Adenosine 3',5'-diphosphate
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401)	Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Neutrophil count ( 32888494)
Interacting Genes		9 interacting genes: CDC5L MAGI1 NCK1 NCK2 NONO NUFIP2 SGF29 YWHAG YWHAZ	2 interacting genes: LCOR RUNX1
Entrez ID		11346	3340
HPRD ID		12179	02912
Ensembl ID		ENSG00000171992	ENSG00000070614
Uniprot IDs		Q8N3V7	A8K8T3 P52848
PDB IDs			1NST 8CCY 8CD0 8CHS
Enriched GO Terms of Interacting Partners?		Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Protein Sequestering Activity Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Protein Domain Specific Binding Response To Stress Positive Regulation Of Translation In Response To Stress Receptor Tyrosine Kinase Binding Signal Complex Assembly Cellular Response To Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation Positive Regulation Of Cell-cell Adhesion Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Intracellular Signal Transduction Cytoskeletal Anchor Activity Regulation Of Translation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Signal Transduction Positive Regulation Of Translation Negative Regulation Of Cell Communication Negative Regulation Of Signaling RNA Binding Signaling Receptor Complex Adaptor Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Intrinsic Apoptotic Signaling Pathway Lamellipodium Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Vesicle Membrane Positive Regulation Of Response To Endoplasmic Reticulum Stress Lamellipodium Organization Response To Endoplasmic Reticulum Stress Positive Regulation Of Translational Initiation Positive Regulation Of Actin Filament Polymerization Molecular Condensate Scaffold Activity Cellular Response To Glucose Starvation Negative Regulation Of Response To Endoplasmic Reticulum Stress Ephrin Receptor Signaling Pathway Innate Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Gene Expression Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Intracellular Signal Transduction Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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