SP5 and NKX3-1

Number of citations of the paper that reports this interaction (PubMedID 16201967)
47

Data Source:
BioGRID (two hybrid)

		SP5	NKX3-1
Description		Sp5 transcription factor	NK3 homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Cytosol Site Of DNA Damage
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding MADS Box Domain Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Post-anal Tail Morphogenesis Bone Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Metanephros Development Somitogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Salivary Gland Development Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Androgen Receptor Signaling Pathway Prostate Gland Development Regulation Of Protein Localization Response To Testosterone Response To Lipid Dorsal Aorta Development Regulation Of Cell Population Proliferation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Positive Regulation Of Androgen Secretion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases			Prostate cancer
GWAS		Ear morphology ( 26105758) Lobe attachment ( 26105758) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Lobe size ( 26105758) Metabolite levels ( 23823483) Urate levels in obese individuals ( 25811787)	Birth weight ( 31043758) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Prostate cancer ( 26443449 32986714 34012061) Prostate-specific antigen levels ( 28139693) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		1 interacting genes: NKX3-1	38 interacting genes: AEN CCT7 CD200R1L CENPX CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 MRE11 MT-ND4 PEBP1 PTMS RABL6 RARG RHOXF2 RNF4 RPL37A RPSA SLC67A1 SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 TEX264 TOPORS TPT1 WDR77 ZNF417
Entrez ID		389058	4824
HPRD ID		18088	03620
Ensembl ID		ENSG00000204335	ENSG00000167034
Uniprot IDs		Q6BEB4	Q99801
PDB IDs			2L9R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Androgen Secretion MADS Box Domain Binding Dorsal Aorta Development Salivary Gland Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Prostate Gland Development Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Branching Involved In Prostate Gland Morphogenesis Urogenital System Development Prostate Gland Development Pharyngeal System Development Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Prostate Gland Epithelium Morphogenesis Androgen Receptor Signaling Pathway Aorta Development Somitogenesis Artery Development Metanephros Development Nuclear Estrogen Receptor Binding Site Of DNA Damage Transcription Regulator Inhibitor Activity Response To Testosterone Cellular Response To Interleukin-1 Segmentation Nuclear Receptor Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Xenobiotic Stimulus Negative Regulation Of Reproductive Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Lipid Transport Positive Regulation Of Cell Division Nuclear Receptor-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Male Gonad Development Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Decreased Oxygen Levels Blood Vessel Development Cellular Response To Hypoxia Response To Tumor Necrosis Factor Histone Deacetylase Binding Positive Regulation Of Mitotic Cell Cycle Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Epithelial Cell Proliferation Regulation Of Lipid Transport	Nucleus DNA Binding PML Body Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Trachea Cartilage Development Sequence-specific Double-stranded DNA Binding Embryonic Eye Morphogenesis Glandular Epithelial Cell Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Double-stranded DNA Binding Regulation Of Programmed Cell Death DNA Damage Response Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Eye Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sensory Organ Morphogenesis Columnar/cuboidal Epithelial Cell Development Embryonic Camera-type Eye Morphogenesis Zinc Ion Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Trophectodermal Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Face Development Regulation Of Macromolecule Biosynthetic Process Prostate Gland Epithelium Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Macromolecule Metabolic Process Signal Transduction By P53 Class Mediator Cellular Response To Stress Replication Fork Positive Regulation Of Macromolecule Metabolic Process Mitochondrial Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Thyroid Gland Development
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