SP5

Description		Sp5 transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Post-anal Tail Morphogenesis Bone Morphogenesis
Pathways
Drugs
Diseases
GWAS		Ear morphology ( 26105758) Lobe attachment ( 26105758) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Lobe size ( 26105758) Metabolite levels ( 23823483) Urate levels in obese individuals ( 25811787)
Interacting Genes		1 interacting genes: NKX3-1
Entrez ID		389058
HPRD ID		18088
Ensembl ID		ENSG00000204335
Uniprot IDs		Q6BEB4
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Androgen Secretion MADS Box Domain Binding Dorsal Aorta Development Salivary Gland Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Prostate Gland Development Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Branching Involved In Prostate Gland Morphogenesis Urogenital System Development Prostate Gland Development Pharyngeal System Development Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Prostate Gland Epithelium Morphogenesis Androgen Receptor Signaling Pathway Aorta Development Somitogenesis Artery Development Metanephros Development Nuclear Estrogen Receptor Binding Site Of DNA Damage Transcription Regulator Inhibitor Activity Response To Testosterone Cellular Response To Interleukin-1 Segmentation Nuclear Receptor Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Xenobiotic Stimulus Negative Regulation Of Reproductive Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Lipid Transport Positive Regulation Of Cell Division Nuclear Receptor-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Male Gonad Development Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Decreased Oxygen Levels Blood Vessel Development Cellular Response To Hypoxia Response To Tumor Necrosis Factor Histone Deacetylase Binding Positive Regulation Of Mitotic Cell Cycle Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Epithelial Cell Proliferation Regulation Of Lipid Transport
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