CERS3

Description		ceramide synthase 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Epidermis Development Sphingolipid Biosynthetic Process Keratinocyte Differentiation Ceramide Biosynthetic Process Cornification
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Childhood body mass index ( 31752434) Cotinine glucuronidation ( 25293881)
Interacting Genes		5 interacting genes: NEU1 ORMDL3 PCBD2 SLC29A2 SLC39A9
Entrez ID		204219
HPRD ID		13961
Ensembl ID		ENSG00000154227
Uniprot IDs		Q8IU89
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytidine Transmembrane Transporter Activity Uracil Transmembrane Transport Thymine Transport Uridine Transmembrane Transport Inosine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Cytidine Transport Uracil Transmembrane Transporter Activity Adenine Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transport Guanine Transmembrane Transporter Activity Pyrimidine Nucleoside Transport Guanine Transport Guanine Transmembrane Transport Adenosine Transport Hypoxanthine Transport Nucleoside Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity Membrane Lipid Metabolic Process Alpha-sialidase Activity Sphingolipid Metabolic Process Ceramide Metabolic Process Exo-alpha-sialidase Activity Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Androgen Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Negative Regulation Of Ceramide Biosynthetic Process Intracellular Sphingolipid Homeostasis Nucleoside Transmembrane Transport Adenine Transport Nucleoside Transport Pyrimidine Nucleobase Transport Negative Regulation Of Sphingolipid Biosynthetic Process Purine Nucleobase Transmembrane Transport Tetrahydrobiopterin Biosynthetic Process Serine Palmitoyltransferase Complex Ganglioside Catabolic Process Tetrahydrobiopterin Metabolic Process Purine Nucleobase Transport Nucleobase Transport Sphingomyelin Biosynthetic Process Pyrimidine-containing Compound Transmembrane Transport Pteridine-containing Compound Biosynthetic Process Negative Regulation Of B Cell Apoptotic Process Regulation Of Ceramide Biosynthetic Process Xenobiotic Transmembrane Transport Oligosaccharide Catabolic Process
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