CERS3 and SLC29A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CERS3	SLC29A2
Description		ceramide synthase 3	solute carrier family 29 member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleolus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity	Neurotransmitter Transmembrane Transporter Activity Nucleoside Transmembrane Transporter Activity Nucleobase Transmembrane Transporter Activity Adenine Transmembrane Transporter Activity Guanine Transmembrane Transporter Activity Uracil Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transporter Activity Cytidine Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Epidermis Development Sphingolipid Biosynthetic Process Keratinocyte Differentiation Ceramide Biosynthetic Process Cornification	Neurotransmitter Uptake Neurotransmitter Transport Xenobiotic Transmembrane Transport Nucleobase Transport Adenine Transport Guanine Transport Nucleoside Transport Purine Nucleoside Transmembrane Transport Cytidine Transport Uridine Transmembrane Transport Adenosine Transport Inosine Transport Hypoxanthine Transport Thymine Transport Pyrimidine-containing Compound Transmembrane Transport Transport Across Blood-brain Barrier Nucleoside Transmembrane Transport Guanine Transmembrane Transport Uracil Transmembrane Transport Purine Nucleobase Transmembrane Transport
Pathways		Sphingolipid de novo biosynthesis	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Azathioprine ADME
Drugs			Ethanol
Diseases
GWAS		Childhood body mass index ( 31752434) Cotinine glucuronidation ( 25293881)	Bipolar disorder ( 21926972) Serum metabolite levels ( 33031748) Serum uric acid levels ( 32514006)
Interacting Genes		5 interacting genes: NEU1 ORMDL3 PCBD2 SLC29A2 SLC39A9	19 interacting genes: ALOX5AP CERS3 CERS4 CREB3 ERGIC3 GJA4 GPR152 LAPTM4B PLPP5 SERINC2 SLC10A1 SLC10A6 TMEM237 TMEM242 TMEM33 TMEM86B TMX2 UBQLN1 UBQLN2
Entrez ID		204219	3177
HPRD ID		13961	03662
Ensembl ID		ENSG00000154227	ENSG00000174669
Uniprot IDs		Q8IU89	Q14542 Q96FB2
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytidine Transmembrane Transporter Activity Uracil Transmembrane Transport Thymine Transport Uridine Transmembrane Transport Inosine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Cytidine Transport Uracil Transmembrane Transporter Activity Adenine Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transport Guanine Transmembrane Transporter Activity Pyrimidine Nucleoside Transport Guanine Transport Guanine Transmembrane Transport Adenosine Transport Hypoxanthine Transport Nucleoside Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity Membrane Lipid Metabolic Process Alpha-sialidase Activity Sphingolipid Metabolic Process Ceramide Metabolic Process Exo-alpha-sialidase Activity Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Androgen Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Negative Regulation Of Ceramide Biosynthetic Process Intracellular Sphingolipid Homeostasis Nucleoside Transmembrane Transport Adenine Transport Nucleoside Transport Pyrimidine Nucleobase Transport Negative Regulation Of Sphingolipid Biosynthetic Process Purine Nucleobase Transmembrane Transport Tetrahydrobiopterin Biosynthetic Process Serine Palmitoyltransferase Complex Ganglioside Catabolic Process Tetrahydrobiopterin Metabolic Process Purine Nucleobase Transport Nucleobase Transport Sphingomyelin Biosynthetic Process Pyrimidine-containing Compound Transmembrane Transport Pteridine-containing Compound Biosynthetic Process Negative Regulation Of B Cell Apoptotic Process Regulation Of Ceramide Biosynthetic Process Xenobiotic Transmembrane Transport Oligosaccharide Catabolic Process	Membrane Regulation Of Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Membrane Endoplasmic Reticulum Bile Acid:sodium Symporter Activity Positive Regulation Of Response To Endoplasmic Reticulum Stress Sphingosine N-acyltransferase Activity Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Bile Acid And Bile Salt Transport Regulation Of ERAD Pathway Positive Regulation Of Deacetylase Activity Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Store-operated Calcium Channel Activity D-lysine 5,6-aminomutase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Leukotriene Production Involved In Inflammatory Response Regulation Of Vacuole Organization Negative Regulation Of G Protein-coupled Receptor Internalization Retrograde Transporter Complex, Golgi To ER Regulation Of Lysosomal Membrane Permeability Ceramide Biosynthetic Process Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity
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