NDUFA5 and IRF5

Data Source: HiPPIP (Novel)

		NDUFA5	IRF5
Name		NADH:ubiquinone oxidoreductase subunit A5	interferon regulatory factor 5
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Protein-containing Complex Respiratory Chain Complex I	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Sequence-specific DNA Binding Protein Serine/threonine Kinase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Respiratory Electron Transport Chain Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Cellular Response To Virus
Pathways		Respiratory electron transport Complex I biogenesis RHOG GTPase cycle	Interferon gamma signaling Interferon alpha/beta signaling SLC15A4:TASL-dependent IRF5 activation
Drugs		NADH	None
GWAS		No GWAS studies recorded	Autoimmune traits (pleiotropy) ( 30572963 ) Behcet's disease ( 33393726 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Diffuse cutaneous systemic sclerosis ( 29293537 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Estimated glomerular filtration rate ( 31152163 ) Limited cutaneous systemic scleroderma ( 29293537 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Primary biliary cholangitis ( 20639880 26394269 21399635 ) Primary biliary cirrhosis ( 22961000 ) Rheumatoid arthritis ( 30423114 24390342 23143596 30572963 21156761 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Sjögren's syndrome ( 24097067 28076899 ) Systemic lupus erythematosus ( 26502338 28714469 32771030 27399966 33272962 26663301 18204098 18204446 19838193 19838195 21408207 23053960 23273568 26606652 24871463 ) Systemic lupus erythematosus and Systemic sclerosis ( 23740937 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 ) Systemic sclerosis ( 24387989 20383147 31672989 21750679 30572963 21779181 30247649 29293537 ) Systemic sclerosis (anti-centromere-positive) ( 29293537 ) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655 ) Ulcerative colitis ( 23128233 28067908 21297633 26398853 )
Interacting Genes		9 interacting genes: APP CBY2 CCDC85B COG6 DAZAP2 GOLGA2 NDUFB1 PLEKHF2 TTR	17 interacting genes: ALPI COPS3 CREBBP EP300 HDAC1 IKBKE IRF3 MAVS MYD88 NCOR2 SGTA SIN3A TBK1 TRAF6 TRIM15 TRIM21 XPO1
Entrez ID		4698	3663
HPRD ID		03398	06240
Ensembl ID		ENSG00000128609	ENSG00000128604
Uniprot IDs		A0A024R772 A0A087WXR5 A0A087X1G1 Q16718	A0A0G2USB5 B7Z1M2 Q13568
PDB IDs		5XTB 5XTD 5XTH 5XTI	3DSH
GO Terms Enriched among Interactors		Protein Serine/threonine Kinase Binding	Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response Canonical NF-kappaB Signal Transduction Interferon-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Regulation Of Defense Response Defense Response To Virus Innate Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway Response To Virus Antiviral Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-activating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway MRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Histone H3K27 Acetyltransferase Activity Positive Regulation Of Response To Cytokine Stimulus Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cytokine Production Protein-containing Complex Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell Communication Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Signaling