MYBL2 and LIN9

Number of citations of the paper that reports this interaction (PubMedID 17159899)
43

Data Source:
HPRD (in vivo)

		MYBL2	LIN9
Description		MYB proto-oncogene like 2	lin-9 DREAM MuvB core complex component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Myb Complex	Nucleus Nucleoplasm Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Protein Binding
	Biological Process	Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Mitotic Spindle Assembly Cellular Response To Leukemia Inhibitory Factor	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle DNA Biosynthetic Process
Pathways		Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Polo-like kinase mediated events TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Fasting insulin ( 34059833) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Caudate nucleus volume ( 31530798) Gut microbiota beta diversity (weighted UniFrac distance) ( 33208821) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494) Nicotine dependence symptom count ( 25555482)
Interacting Genes		29 interacting genes: CCNA1 CCNA2 CCND1 CCNE1 CCNF CDC34 CDK2 CDK9 CREBBP CXCR4 E2F1 E2F3 EP300 LIN9 LZTR1 MAP1LC3B MAPK6 NCOR1 NCOR2 PARP1 RBL1 SKP2 SND1 TRIM15 TTF2 UBB UBE2D4 ZBTB9 ZNF622	3 interacting genes: MYBL2 RB1 RBBP4
Entrez ID		4605	286826
HPRD ID		03247	13990
Ensembl ID		ENSG00000101057	ENSG00000183814
Uniprot IDs		P10244	H0Y322 Q5TKA1 Q6P142
PDB IDs		6C48	6C48 7N40 7R1D
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin A2-CDK2 Complex Nucleus Protein Modification Process Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm Post-translational Protein Modification Transcription Regulator Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Microtubule Organizing Center Nucleic Acid Metabolic Process DNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Cyclin A1-CDK2 Complex Histone H3K27 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Transcription Repressor Complex Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle DNA-templated Transcription Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Kinase Binding Cyclin E1-CDK2 Complex Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Re-entry Into Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Transcription Pausing By RNA Polymerase II Negative Regulation Of Fat Cell Proliferation Regulation Of RNA Metabolic Process DNA Damage Response Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination RNA Metabolic Process	Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Myb Complex Negative Regulation Of Myofibroblast Differentiation Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process Enucleate Erythrocyte Differentiation Glial Cell Apoptotic Process Rb-E2F Complex Regulation Of Centromere Complex Assembly Chromatin Lock Complex Positive Regulation Of Collagen Fibril Organization CAF-1 Complex DNA Replication-dependent Chromatin Assembly NURF Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Myofibroblast Differentiation Regulation Of Collagen Fibril Organization Cyclin/CDK Positive Transcription Elongation Factor Complex Importin-alpha Family Protein Binding Positive Regulation Of Transcription Regulatory Region DNA Binding ATPase Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macrophage Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Hepatocyte Apoptotic Process Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Glial Cell Proliferation ESC/E(Z) Complex NuRD Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of DNA Binding Cell Morphogenesis Involved In Neuron Differentiation Sin3-type Complex Regulation Of Cell Fate Specification Chromatin Remodeling Regulation Of Macrophage Differentiation Negative Regulation Of Stem Cell Population Maintenance Disordered Domain Specific Binding Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Epithelial Cell Apoptotic Process Glial Cell Proliferation Negative Regulation Of Cell Population Proliferation Neuron Maturation SWI/SNF Complex
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