MYBL2

Description		MYB proto-oncogene like 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Myb Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Mitotic Spindle Assembly Cellular Response To Leukemia Inhibitory Factor
Pathways		Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Polo-like kinase mediated events TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs
Diseases
GWAS		Fasting insulin ( 34059833) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		29 interacting genes: CCNA1 CCNA2 CCND1 CCNE1 CCNF CDC34 CDK2 CDK9 CREBBP CXCR4 E2F1 E2F3 EP300 LIN9 LZTR1 MAP1LC3B MAPK6 NCOR1 NCOR2 PARP1 RBL1 SKP2 SND1 TRIM15 TTF2 UBB UBE2D4 ZBTB9 ZNF622
Entrez ID		4605
HPRD ID		03247
Ensembl ID		ENSG00000101057
Uniprot IDs		P10244
PDB IDs		6C48
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin A2-CDK2 Complex Nucleus Protein Modification Process Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm Post-translational Protein Modification Transcription Regulator Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Microtubule Organizing Center Nucleic Acid Metabolic Process DNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Cyclin A1-CDK2 Complex Histone H3K27 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Transcription Repressor Complex Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle DNA-templated Transcription Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Kinase Binding Cyclin E1-CDK2 Complex Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Re-entry Into Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Transcription Pausing By RNA Polymerase II Negative Regulation Of Fat Cell Proliferation Regulation Of RNA Metabolic Process DNA Damage Response Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination RNA Metabolic Process
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