MVK and SELPLG

Data Source: HiPPIP (Novel)

		MVK	SELPLG
Name		mevalonate kinase	selectin P ligand
Structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol	Uropod Plasma Membrane Membrane Plasma Membrane Raft
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Mevalonate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding	Virus Receptor Activity Signaling Receptor Binding Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Sterol Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Negative Regulation Of Inflammatory Response	Cell Adhesion Symbiont Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling Leukocyte Adhesive Activation Cellular Response To Interleukin-6
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Cell surface interactions at the vascular wall
Drugs		Farnesyl thiopyrophosphate	Neihulizumab
Diseases		Mevalonate kinase deficiency; Hyperimmunoglobulinemia D; Mevalonic aciduria	None
GWAS		Aspartate aminotransferase levels ( 29403010 ) Cataracts ( 34127677 ) Fish- and plant-related diet ( 32066663 ) HDL cholesterol ( 19060906 30275531 25961943 24097068 20864672 20686565 18193043 ) HDL cholesterol levels ( 28334899 ) High density lipoprotein cholesterol levels ( 29403010 ) Low density lipoprotein cholesterol levels ( 32154731 ) Mean platelet volume ( 32888494 ) Neutrophil count ( 29403010 ) Non-oily fish consumption ( 32066663 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Red cell distribution width ( 28957414 ) Serum metabolite levels ( 33031748 )	Acne (severe) ( 24927181 ) Blood protein levels ( 30072576 ) Brain morphology (MOSTest) ( 32665545 ) Conduct disorder (symptom count) ( 20585324 )
Novel Interactors		5 novel interactors: EIF4E2 GLTP HIP1R PTPN11 SELPLG	3 novel interactors: CIT ECSIT MVK
Interacting Genes		5 interacting genes: CEBPA EWSR1 POT1 RNF141 TERF1	14 interacting genes: BACE1 CTSG GALNT4 MAGEA1 MSN SELE SELL SELP SLC13A1 SYK TNIP1 TPST1 TPST2 VCAN
Entrez ID		4598	6404
HPRD ID		02015	02845
Ensembl ID		ENSG00000110921	ENSG00000110876
Uniprot IDs		B2RDU6 B7Z1C2 B7Z301 F5H8H2 Q03426	Q14242
PDB IDs		2R3V	1G1S
GO Terms Enriched among Interactors		Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Inner Ear Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Clathrin Coat Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Intestinal Epithelial Cell Migration Leukocyte Adhesive Activation Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Biosynthetic Process Positive Regulation Of Telomeric Loop Disassembly DNA Biosynthetic Process Cytokine-mediated Signaling Pathway CHOP-C/EBP Complex Regulation Of Protein-containing Complex Assembly Cerebellar Cortex Formation Telomere Maintenance Positive Regulation Of Chromosome Organization Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Clathrin Coat Assembly 8-hydroxy-2'-deoxyguanosine DNA Binding	Leukocyte Cell-cell Adhesion Leukocyte Migration Oligosaccharide Binding Carbohydrate Binding Leukocyte Tethering Or Rolling Sialic Acid Binding Protein-tyrosine Sulfotransferase Activity Leukocyte Adhesion To Vascular Endothelial Cell Cell-cell Adhesion Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Glycosphingolipid Binding Regulation Of Platelet Activation Cell Motility Positive Regulation Of Leukocyte Tethering Or Rolling Regulation Of Leukocyte Tethering Or Rolling 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Golgi Lumen Response To Lipopolysaccharide Immune System Process Phospholipase Binding Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Response To Molecule Of Bacterial Origin Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Neutrophil Activation Positive Regulation Of Receptor Internalization Regulation Of Platelet Aggregation Regulation Of Leukocyte Cell-cell Adhesion Heparin Binding Regulation Of Immune System Process Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Pattern Recognition Receptor Signaling Pathway Regulation Of Inflammatory Response Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Innate Immune Response-activating Signaling Pathway Trans-Golgi Network Signaling Receptor Ligand Precursor Processing Response To Lipid Biofilm Matrix Disassembly Regulation Of Defense Response Mevalonate Kinase Activity Interleukin-15 Receptor Binding Positive Regulation Of Interleukin-3 Production Peptidyl-tyrosine Sulfation Golgi-associated Vesicle Lumen Activation Of Innate Immune Response Response To External Biotic Stimulus