MVK and RNF141

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MVK	RNF141
Description		mevalonate kinase	ring finger protein 141
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GO Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol	Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Mevalonate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Sterol Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Negative Regulation Of Inflammatory Response	Regulation Of DNA-templated Transcription Protein Autoubiquitination
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		Farnesyl thiopyrophosphate
Diseases		Mevalonate kinase deficiency; Hyperimmunoglobulinemia D; Mevalonic aciduria
GWAS		Aspartate aminotransferase levels ( 29403010) Cataracts ( 34127677) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 19060906 30275531 25961943 24097068 20864672 20686565 18193043) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Neutrophil count ( 29403010) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 28957414) Serum metabolite levels ( 33031748)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		5 interacting genes: CEBPA EWSR1 POT1 RNF141 TERF1	8 interacting genes: DTX3 KRAS MAP3K1 MVK PLK3 SMURF1 TRIM24 TRIM8
Entrez ID		4598	50862
HPRD ID		02015	11509
Ensembl ID		ENSG00000110921	ENSG00000110315
Uniprot IDs		B2RDU6 B7Z1C2 B7Z301 F5H8H2 Q03426	Q8WVD5
PDB IDs		2R3V	2ECN 5XEK
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Inner Ear Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Clathrin Coat Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Intestinal Epithelial Cell Migration Leukocyte Adhesive Activation Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Biosynthetic Process Positive Regulation Of Telomeric Loop Disassembly DNA Biosynthetic Process Cytokine-mediated Signaling Pathway CHOP-C/EBP Complex Regulation Of Protein-containing Complex Assembly Cerebellar Cortex Formation Telomere Maintenance Positive Regulation Of Chromosome Organization Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Clathrin Coat Assembly 8-hydroxy-2'-deoxyguanosine DNA Binding	Transferase Activity Protein Modification Process Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation P53 Binding Positive Regulation Of Chaperone-mediated Autophagy Protein Metabolic Process Mevalonate Kinase Activity Histone H3K23ac Reader Activity Post-translational Protein Modification Engulfment Of Target By Autophagosome Cytoplasm Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase Activity Regulation Of Signal Transduction By P53 Class Mediator Endomitotic Cell Cycle GMP Binding Forebrain Astrocyte Development Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Isolation Stress Kinase Activity Isopentenyl Diphosphate Biosynthetic Process Isopentenyl Diphosphate Metabolic Process Perichromatin Fibrils Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Golgi Disassembly LRR Domain Binding Activin Receptor Binding Response To Gravity
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