MVK

Name	mevalonate kinase
Structure
Novel Interactors	5 novel interactors: EIF4E2 GLTP HIP1R PTPN11 SELPLG
Interactors	5 interactors: CEBPA EWSR1 POT1 RNF141 TERF1
GO Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Mevalonate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Sterol Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Negative Regulation Of Inflammatory Response
Pathways	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs	Farnesyl thiopyrophosphate
Diseases	Mevalonate kinase deficiency; Hyperimmunoglobulinemia D; Mevalonic aciduria
GWAS	Aspartate aminotransferase levels ( 29403010 ) Cataracts ( 34127677 ) Fish- and plant-related diet ( 32066663 ) HDL cholesterol ( 19060906 30275531 25961943 24097068 20864672 20686565 18193043 ) HDL cholesterol levels ( 28334899 ) High density lipoprotein cholesterol levels ( 29403010 ) Low density lipoprotein cholesterol levels ( 32154731 ) Mean platelet volume ( 32888494 ) Neutrophil count ( 29403010 ) Non-oily fish consumption ( 32066663 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Red cell distribution width ( 28957414 ) Serum metabolite levels ( 33031748 )
Entrez ID	4598
HPRD ID	02015
Ensembl ID	ENSG00000110921
Uniprot IDs	B2RDU6 B7Z1C2 B7Z301 F5H8H2 Q03426
PDB IDs	2R3V
GO Terms Enriched among Interactors ?	Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Inner Ear Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Clathrin Coat Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Intestinal Epithelial Cell Migration Leukocyte Adhesive Activation Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Biosynthetic Process Positive Regulation Of Telomeric Loop Disassembly DNA Biosynthetic Process Cytokine-mediated Signaling Pathway CHOP-C/EBP Complex Regulation Of Protein-containing Complex Assembly Cerebellar Cortex Formation Telomere Maintenance Positive Regulation Of Chromosome Organization Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Clathrin Coat Assembly 8-hydroxy-2'-deoxyguanosine DNA Binding