MVK

Gene Name		mevalonate kinase
Image
Gene Ontology Annotations	Cellular Component	Peroxisome Cytosol Extracellular Vesicular Exosome
	Molecular Function	Mevalonate Kinase Activity ATP Binding Identical Protein Binding
	Biological Process	Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Phosphorylation Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Small Molecule Metabolic Process Negative Regulation Of Inflammatory Response
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Cholesterol biosynthesis Metabolism of lipids and lipoproteins Activation of gene expression by SREBF (SREBP)
Drugs
Diseases
GWAS		HDL cholesterol ( 18193043 20864672 19060906 20686565)
Protein-protein Interactions		3 interactors: EWSR1 POT1 TERF1
Entrez ID		4598
HPRD ID		02015
Ensembl ID		ENSG00000110921
Uniprot IDs		B2RDU6 F5H8H2 Q03426
PDB IDs		2R3V
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Positive Regulation Of DNA Strand Elongation Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Telomere Formation Via Telomerase Age-dependent Telomere Shortening DNA Replication Telomere Maintenance Via Telomere Shortening Negative Regulation Of Transferase Activity Positive Regulation Of Helicase Activity Telomere Capping Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Organelle Organization Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Positive Regulation Of Microtubule Polymerization Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Catalytic Activity Cellular Macromolecule Biosynthetic Process Regulation Of Microtubule Polymerization Macromolecule Biosynthetic Process Mitotic Spindle Assembly Checkpoint Regulation Of Organelle Organization Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Chromosome Organization DNA Metabolic Process Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation
Tagcloud ?		butyl chemicals cytokeratins dcvc dichlorovinyl extend gadd153 generations hpt hsp27 hydroperoxide ketone modest necrotic nephrotoxicant oxidants p0 p1 p2 p4 passage passaged prominently retained slowed successively tbh tert vinyl