MVD and HSPA9

Number of citations of the paper that reports this interaction (PMID 12646231)
9

Data Source:
HPRD (two hybrid, in vivo)

		MVD	HSPA9
Gene Name		mevalonate (diphospho) decarboxylase	heat shock 70kDa protein 9 (mortalin)
Image
Gene Ontology Annotations	Cellular Component	Peroxisome Cytosol	Nucleolus Cytoplasm Mitochondrion Focal Adhesion Mitochondrial Nucleoid Extracellular Vesicular Exosome
	Molecular Function	Diphosphomevalonate Decarboxylase Activity ATP Binding Hsp70 Protein Binding Protein Homodimerization Activity	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Cholesterol Biosynthetic Process Positive Regulation Of Cell Proliferation Isoprenoid Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process	Protein Folding Protein Export From Nucleus Protein Targeting To Mitochondrion Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process
Pathways		Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Regulation of cholesterol biosynthesis by SREBP (SREBF) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Synthesis of Dolichyl-phosphate Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Cholesterol biosynthesis Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Activation of gene expression by SREBF (SREBP) Diseases associated with N-glycosylation of proteins	Mitochondrial protein import
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BTAF1 EEF1G EIF4EBP1 GNB5 HSPA9	15 interactors: APP DNAJA3 DNAJC19 DNLZ FGF1 HSP90B1 HSPBP1 LSM8 MVD NELFB SUMO4 TP53 XPO1 YKT6 YWHAG
Entrez ID		4597	3313
HPRD ID		04454	02770
Ensembl ID		ENSG00000167508	ENSG00000113013
Uniprot IDs		P53602	P38646
PDB IDs		3D4J	3N8E
Enriched GO Terms of Interacting Partners?			Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Protein Folding Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Localization Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Mitochondrial DNA Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Protein Transport Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Transport Mitochondrial Genome Maintenance Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Catalytic Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Localization Response To Abiotic Stimulus Positive Regulation Of Cellular Metabolic Process Neuromuscular Junction Development Neuron Apoptotic Process Positive Regulation Of Mitochondrion Organization Cytoplasmic Transport Establishment Of Localization In Cell Immune Response Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Proteolysis Neuron Death T Cell Differentiation In Thymus Negative Regulation Of Cellular Metabolic Process Cellular Protein Localization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Aging Innate Immune Response Membrane Organization Negative Regulation Of Macromitophagy Synaptic Growth At Neuromuscular Junction Actin Rod Assembly Oligodendrocyte Apoptotic Process Regulation Of Mitochondrion Organization Mitochondrion Organization Negative Regulation Of Hydrolase Activity Intracellular Protein Transport
Tagcloud ?		aggressive analyse bcc behavior carcinomas exceeded explain fact immunohistochemically indicator ka keratoacanthomas metastatic microvessel neoplasms nod nodular paraffin perilesional psmvd scc scl sclerosing sections slow stained tmvd vascularized viii	5q 5q31 cfu collectively colony comprehensively defect del deleted haploinsufficiency haploinsufficient hematopoiesis heterozygous homozygous implicate intrinsic knockdown knockout lethal lymphopoiesis malignancies observe preb progenitors rnai stat5 supporting viable zebrafish
Tagcloud (Difference) ?		aggressive analyse bcc behavior carcinomas exceeded explain fact immunohistochemically indicator ka keratoacanthomas metastatic microvessel neoplasms nod nodular paraffin perilesional psmvd scc scl sclerosing sections slow stained tmvd vascularized viii	5q 5q31 cfu collectively colony comprehensively defect del deleted haploinsufficiency haploinsufficient hematopoiesis heterozygous homozygous implicate intrinsic knockdown knockout lethal lymphopoiesis malignancies observe preb progenitors rnai stat5 supporting viable zebrafish
Tagcloud (Intersection) ?