MVD and HSPA9

Number of citations: 0 (PubMedID 12646231)
Data Source: HPRD (two hybrid, in vivo)

		MVD	HSPA9
Name		mevalonate diphosphate decarboxylase	heat shock protein family A (Hsp70) member 9
Structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol	SAM Complex Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Matrix Focal Adhesion Mitochondrial Nucleoid Extracellular Exosome MIB Complex
	Molecular Function	Nucleotide Binding Diphosphomevalonate Decarboxylase Activity ATP Binding Lyase Activity Carboxy-lyase Activity Hsp70 Protein Binding Protein Homodimerization Activity	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Isoprenoid Biosynthetic Process Sterol Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway	Protein Folding Protein Export From Nucleus Intracellular Protein Transport Inner Mitochondrial Membrane Organization Iron-sulfur Cluster Assembly Erythrocyte Differentiation Calcium Import Into The Mitochondrion Protein Refolding Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Hemopoiesis
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP) Synthesis of dolichyl-phosphate	Mitochondrial protein import Regulation of HSF1-mediated heat shock response Complex I biogenesis Cristae formation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt) Complex III assembly
GWAS		Feeling fed-up ( 29500382 ) Hair color ( 26926045 )	Autism spectrum disorder or schizophrenia ( 28540026 ) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321 ) Schizophrenia ( 25056061 29483656 )
Novel Interactors		1 novel interactors: TUBB3	5 novel interactors: GDF9 IL3 IL4 IL5 IL9
Interacting Genes		5 interacting genes: BTAF1 EEF1G EIF4EBP1 GNB5 HSPA9	31 interacting genes: APP DNAJC19 DNLZ ERBB2 ERCC6 FGF1 HSP90B1 HSPBP1 LAMTOR5 LCOR LINC01554 LSM8 MATK MVD NEDD8 NELFB OGT PTPN11 PTPRF RNF10 RNF26 SIRPA STUB1 SUMO2 SUMO4 SUPT6H TP53 USP7 XPO1 YKT6 YWHAG
Entrez ID		4597	3313
HPRD ID		04454	02770
Ensembl ID		ENSG00000167508	ENSG00000113013
Uniprot IDs		P53602	A0A384P5G6 P38646
PDB IDs		3D4J	3N8E 4KBO 6NHK 6P2U 6PMT 9BLS 9BLT 9BLU
GO Terms Enriched among Interactors		Negative Regulation Of Chromatin Binding Netrin Receptor Binding GTPase Activator Complex G-protein Gamma-subunit Binding Dark Adaptation Light Adaption Negative Regulation Of Hematopoietic Stem Cell Differentiation Dorsal Root Ganglion Development	Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Growth Factor Activity Regulation Of Phosphorus Metabolic Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Protein Tag Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Receptor Tyrosine Kinase Binding Protein Modification By Small Protein Conjugation TORC1 Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Protein-containing Complex Positive Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process TOR Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Intracellular Protein Localization Post-translational Protein Modification Regulation Of Cell Activation Regulation Of TORC1 Signaling Regulation Of Small Molecule Metabolic Process Positive Regulation Of Proteolysis Protein-folding Chaperone Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Cytokine Activity Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Regulation Of Lymphocyte Activation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Protein Metabolic Process Developmental Growth Protein Stabilization Positive Regulation Of Cell Activation Cellular Response To Manganese Ion