MUC6 and TFF1

Number of citations of the paper that reports this interaction (PubMedID 10673290)
38

Data Source:
HPRD (in vitro)

		MUC6	TFF1
Description		mucin 6, oligomeric mucus/gel-forming (gene/pseudogene)	trefoil factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Plasma Membrane Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent	Protein Binding Growth Factor Activity
	Biological Process	Maintenance Of Gastrointestinal Epithelium	Carbohydrate Metabolic Process Signal Transduction Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Iron Ion Cell Differentiation Maintenance Of Gastrointestinal Epithelium Response To Immobilization Stress Response To Peptide Hormone
Pathways		Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Estrogen-dependent gene expression
Drugs			Raloxifene Afimoxifene
Diseases
GWAS		Asthma ( 31959851) Asthma (adult onset) ( 31036433) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)	Blood protein levels ( 30072576) Pancreatic cancer ( 22158540)
Interacting Genes		1 interacting genes: TFF1	20 interacting genes: AKT1 APC ATM BTN3A1 BTNL8 CD300LD ESR2 FCRL4 FGFR2 GKN2 MUC6 RAD51 SGTB SIGLEC8 TSG101 UBQLN1 UBQLN4 VSNL1 XRCC3 ZNF250
Entrez ID		4588	7031
HPRD ID		11830	00219
Ensembl ID		ENSG00000184956	ENSG00000160182
Uniprot IDs		Q6W4X9	P04155
PDB IDs			1HI7 1PS2 6V1D
Enriched GO Terms of Interacting Partners?		Response To Immobilization Stress Maintenance Of Gastrointestinal Epithelium Epithelial Structure Maintenance Response To Iron Ion Digestive System Process	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Regulation Of Macroautophagy Response To Alcohol Regulation Of Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance ATP-dependent DNA Damage Sensor Activity Telomere Maintenance Via Recombination Mitotic Recombination Regulation Of Sister Chromatid Segregation Cellular Response To Stress Cellular Response To Decreased Oxygen Levels Protein Autophosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Response To Stress Identical Protein Binding Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Chromosome Segregation Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Nuclear Division Regulation Of Mitotic Nuclear Division Response To X-ray Cellular Response To Gamma Radiation Regulation Of Double-strand Break Repair Recombinational Repair Autophagy Reciprocal Meiotic Recombination Telomere Organization Regulation Of DNA Recombination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Immune Response-activating Signaling Pathway Cellular Response To Oxygen Levels Negative Regulation Of Macroautophagy Regulation Of Protein Catabolic Process Regulation Of Autophagy Macroautophagy Homologous Recombination Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Macromolecule Catabolic Process Regulation Of TRNA Methylation Negative Regulation Of Mitotic Nuclear Division Meiosis I
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