DHODH

Gene Name		dihydroorotate dehydrogenase (quinone)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane Intrinsic Component Of Mitochondrial Inner Membrane Neuronal Cell Body
	Molecular Function	Dihydroorotate Dehydrogenase Activity Drug Binding FMN Binding Ubiquinone Binding
	Biological Process	Pyrimidine Nucleobase Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Female Pregnancy Lactation Response To Caffeine Response To Drug Response To Starvation Positive Regulation Of Apoptotic Process 'de Novo' UMP Biosynthetic Process Small Molecule Metabolic Process Pyrimidine Nucleoside Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Regulation Of Mitochondrial Fission
Pathways		Pyrimidine biosynthesis Pyrimidine metabolism Metabolism of nucleotides
Drugs		Leflunomide Atovaquone Orotic Acid Decylamine-N,N-Dimethyl-N-Oxide Riboflavin Monophosphate Brequinar Analog 6-Fluoro-2-(2\'-Fluoro-1,1\'-Biphenyl-4-Yl)-3-Methylquinoline-4-Carboxylic Acid Antiproliferative Agent A771726 Lauryl Dimethylamine-N-Oxide 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone 5-(AMINOCARBONYL)-1,1\':4\',1\'\'-TERPHENYL-3-CARBOXYLICACID (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(2,2\'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(3\'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE 2-({[3,5-DIFLUORO-3\'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID 3-{[(3-FLUORO-3\'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID 3-({[3,5-DIFLUORO-3\'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID 2-({[2,3,5,6-TETRAFLUORO-3\'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide (2Z)-N-(3-chloro-2\'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide 3,6,9,12,15-PENTAOXATRICOSAN-1-OL Teriflunomide
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-protein Interactions		2 interactors: MT2A TMED10
Entrez ID		1723
HPRD ID		00521
Ensembl ID		ENSG00000102967
Uniprot IDs		Q02127
PDB IDs		1D3G 1D3H 2B0M 2BXV 2FPT 2FPV 2FPY 2FQI 2PRH 2PRL 2PRM 2WV8 3F1Q 3FJ6 3FJL 3G0U 3G0X 3KVJ 3KVK 3KVL 3KVM 3U2O 3ZWS 3ZWT 4IGH
Enriched GO Terms of Interacting Partners?		Cellular Response To Erythropoietin Cellular Response To Interleukin-3 Cargo Loading Into Vesicle COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Cellular Copper Ion Homeostasis Cellular Response To Zinc Ion COPII Vesicle Coating Regulation Of Beta-amyloid Formation Copper Ion Homeostasis COPII-coated Vesicle Budding Regulation Of Amyloid Precursor Protein Catabolic Process Vesicle Targeting, To, From Or Within Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Vesicle Targeting Localization Within Membrane Response To Zinc Ion Regulated Secretory Pathway Cellular Response To Drug Golgi Organization Membrane Budding ER To Golgi Vesicle-mediated Transport Interferon-gamma-mediated Signaling Pathway Cellular Response To Metal Ion Response To Organic Substance Cellular Response To Inorganic Substance Response To Alkaloid Cellular Response To Interferon-gamma Transition Metal Ion Homeostasis Response To Interferon-gamma
Tagcloud ?		bc1 biosynthesis catalyzed chain cytochrome de dehydrogenase dihydroorotate downregulation electron experiment iii impairment interference leads mitochondrial novo orotate programmed pyrimidine respiratory showing supplementation supported suppression suppressor transport triggered uridine