DHODH and TMED10

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DHODH	TMED10
Gene Name		dihydroorotate dehydrogenase (quinone)	transmembrane emp24-like trafficking protein 10 (yeast)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane Intrinsic Component Of Mitochondrial Inner Membrane Neuronal Cell Body	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Plasma Membrane Integral Component Of Membrane COPI-coated Vesicle Trans-Golgi Network Transport Vesicle Transport Vesicle Membrane Secretory Granule Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Zymogen Granule Membrane Extracellular Vesicular Exosome Gamma-secretase Complex
	Molecular Function	Dihydroorotate Dehydrogenase Activity Drug Binding FMN Binding Ubiquinone Binding	Protein Binding Syntaxin Binding Protein Complex Binding
	Biological Process	Pyrimidine Nucleobase Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Female Pregnancy Lactation Response To Caffeine Response To Drug Response To Starvation Positive Regulation Of Apoptotic Process 'de Novo' UMP Biosynthetic Process Small Molecule Metabolic Process Pyrimidine Nucleoside Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Regulation Of Mitochondrial Fission	Kidney Development Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Golgi Organization Cargo Loading Into Vesicle COPI-coated Vesicle Budding Response To Alkaloid Regulated Secretory Pathway Vesicle Targeting, To, From Or Within Golgi COPI Coating Of Golgi Vesicle COPII Vesicle Coating Protein Oligomerization Regulation Of Beta-amyloid Formation
Pathways		Pyrimidine biosynthesis Pyrimidine metabolism Metabolism of nucleotides
Drugs		Leflunomide Atovaquone Orotic Acid Decylamine-N,N-Dimethyl-N-Oxide Riboflavin Monophosphate Brequinar Analog 6-Fluoro-2-(2\'-Fluoro-1,1\'-Biphenyl-4-Yl)-3-Methylquinoline-4-Carboxylic Acid Antiproliferative Agent A771726 Lauryl Dimethylamine-N-Oxide 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone 5-(AMINOCARBONYL)-1,1\':4\',1\'\'-TERPHENYL-3-CARBOXYLICACID (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(2,2\'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(3\'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE 2-({[3,5-DIFLUORO-3\'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID 3-{[(3-FLUORO-3\'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID 3-({[3,5-DIFLUORO-3\'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID 2-({[2,3,5,6-TETRAFLUORO-3\'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide (2Z)-N-(3-chloro-2\'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide 3,6,9,12,15-PENTAOXATRICOSAN-1-OL Teriflunomide
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)	Height ( 19343178)
Protein-Protein Interactions		2 interactors: MT2A TMED10	15 interactors: APH1A ARCN1 ARF1 COPA COPB1 COPB2 COPE COPG1 COPZ1 DHODH GORASP2 NCSTN PSENEN SEC23B TMED2
Entrez ID		1723	10972
HPRD ID		00521	12013
Ensembl ID		ENSG00000102967	ENSG00000170348
Uniprot IDs		Q02127	B4DL12 P49755
PDB IDs		1D3G 1D3H 2B0M 2BXV 2FPT 2FPV 2FPY 2FQI 2PRH 2PRL 2PRM 2WV8 3F1Q 3FJ6 3FJL 3G0U 3G0X 3KVJ 3KVK 3KVL 3KVM 3U2O 3ZWS 3ZWT 4IGH
Enriched GO Terms of Interacting Partners?		Cellular Response To Erythropoietin Cellular Response To Interleukin-3 Cargo Loading Into Vesicle COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Cellular Copper Ion Homeostasis Cellular Response To Zinc Ion COPII Vesicle Coating Regulation Of Beta-amyloid Formation Copper Ion Homeostasis COPII-coated Vesicle Budding Regulation Of Amyloid Precursor Protein Catabolic Process Vesicle Targeting, To, From Or Within Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Vesicle Targeting Localization Within Membrane Response To Zinc Ion Regulated Secretory Pathway Cellular Response To Drug Golgi Organization Membrane Budding ER To Golgi Vesicle-mediated Transport Interferon-gamma-mediated Signaling Pathway Cellular Response To Metal Ion Response To Organic Substance Cellular Response To Inorganic Substance Response To Alkaloid Cellular Response To Interferon-gamma Transition Metal Ion Homeostasis Response To Interferon-gamma	COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Retrograde Vesicle-mediated Transport, Golgi To ER Membrane Budding Golgi Vesicle Transport Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Establishment Of Organelle Localization Organelle Localization Membrane Organization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Intracellular Protein Transport Protein Localization Intra-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Amyloid Precursor Protein Catabolic Process Membrane Protein Intracellular Domain Proteolysis Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Cellular Localization Notch Receptor Processing Cellular Protein Localization Membrane Protein Proteolysis Organelle Organization Transport Ephrin Receptor Signaling Pathway ER To Golgi Vesicle-mediated Transport Notch Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Protein Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cerebellar Purkinje Cell Layer Maturation Apoptotic Signaling Pathway Axon Guidance Cerebellum Maturation 'de Novo' UMP Biosynthetic Process Body Fluid Secretion Axonogenesis Establishment Of Golgi Localization
Tagcloud ?		bc1 biosynthesis catalyzed chain cytochrome de dehydrogenase dihydroorotate downregulation electron experiment iii impairment interference leads mitochondrial novo orotate programmed pyrimidine respiratory showing supplementation supported suppression suppressor transport triggered uridine	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmem70 y2h
Tagcloud (Difference) ?		bc1 biosynthesis catalyzed chain cytochrome de dehydrogenase dihydroorotate downregulation electron experiment iii impairment interference leads mitochondrial novo orotate programmed pyrimidine respiratory showing supplementation supported suppression suppressor transport triggered uridine	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmem70 y2h
Tagcloud (Intersection) ?