DHODH and TMED10

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DHODH	TMED10
Description		dihydroorotate dehydrogenase (quinone)	transmembrane p24 trafficking protein 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Trans-Golgi Network Transport Vesicle Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Zymogen Granule Membrane Gamma-secretase Complex
	Molecular Function	Dihydroorotase Activity Dihydroorotate Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Dihydroorotate Dehydrogenase (quinone) Activity	Protein Binding Protein Transmembrane Transporter Activity Syntaxin Binding
	Biological Process	'de Novo' Pyrimidine Nucleobase Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process UDP Biosynthetic Process Pyrimidine Ribonucleotide Biosynthetic Process 'de Novo' UMP Biosynthetic Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Protein Transport Vesicle-mediated Transport Positive Regulation Of Interleukin-1 Production Vesicle Cargo Loading COPI-coated Vesicle Budding Regulated Exocytosis Vesicle Targeting, To, From Or Within Golgi COPI Coating Of Golgi Vesicle COPII Vesicle Coating Positive Regulation Of Protein Secretion Protein Transmembrane Transport Protein Localization To ERGIC Cytosol To ERGIC Protein Transport Regulation Of Amyloid-beta Formation
Pathways		Pyrimidine biosynthesis	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Leflunomide Atovaquone Orotic acid Capric dimethyl amine oxide Flavin mononucleotide Brequinar Analog Brequinar Dodecyldimethylamine N-oxide 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone 5-Carbamoyl-1,1':4',1''-terphenyl-3-carboxylic acid SC12267 Manitimus (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide 3,6,9,12,15-PENTAOXATRICOSAN-1-OL Teriflunomide
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bone mineral density (hip) ( 30172743) Fibrinogen levels ( 28107422) Hand grip strength ( 29691431) LDL cholesterol levels in HIV infection ( 33109212) Low density lipoprotein cholesterol levels ( 29403010) Morning person ( 30696823) Number of sexual partners ( 30643258) Total cholesterol levels ( 29403010 33339817)	Coronary artery disease ( 32469254) Heel bone mineral density ( 30598549) Height ( 19343178) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: MT2A RNF19B TMED10 TTPA	20 interacting genes: APH1A ARCN1 ARF1 CDC42 CEBPA COPA COPB1 COPB2 COPE COPG1 COPG2 COPZ1 DHODH FBXO7 NCSTN NPSR1 PSENEN SEC23B SLC13A1 TMED2
Entrez ID		1723	10972
HPRD ID		00521	12013
Ensembl ID		ENSG00000102967	ENSG00000170348
Uniprot IDs		Q02127	A0A024R6I3 P49755
PDB IDs		1D3G 1D3H 2B0M 2BXV 2FPT 2FPV 2FPY 2FQI 2PRH 2PRL 2PRM 2WV8 3F1Q 3FJ6 3FJL 3G0U 3G0X 3KVJ 3KVK 3KVL 3KVM 3U2O 3W7R 3ZWS 3ZWT 4IGH 4JGD 4JS3 4JTS 4JTT 4JTU 4LS0 4LS1 4LS2 4OQV 4RK8 4RKA 4RLI 4RR4 4YLW 4ZL1 4ZMG 5H2Z 5H73 5HIN 5HQE 5K9C 5K9D 5MUT 5MVC 5MVD 5TCE 5ZF4 5ZF7 5ZF8 5ZF9 5ZFA 5ZFB 6CJF 6CJG 6ET4 6FMD 6GK0 6IDJ 6J3B 6J3C 6JMD 6JME 6LP6 6LP7 6LP8 6LZL 6M2B 6OC0 6OC1 6QU7 6SYP 6VND 7K2U 7Z6C 8DHF 8DHG 8DHH 8K4F 8RAK 8VHL 8VHM 8YHR 9BKM 9BKN 9BKO 9DHG 9DHH 9DHI 9DHJ 9I2Y
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Establishment Of Blood-brain Barrier Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Cellular Response To Erythropoietin Cellular Response To Interleukin-3 Response To Erythropoietin Vitamin E Metabolic Process Regulation Of Establishment Of Blood-brain Barrier Vitamin E Binding Gamma-secretase Complex COPI Coating Of Golgi Vesicle Vesicle Targeting, To, From Or Within Golgi Positive Regulation Of Amyloid-beta Clearance Detoxification Of Copper Ion Phosphatidylinositol Bisphosphate Binding Lipid Transfer Activity Cytolytic Granule COPI-coated Vesicle Intracellular Copper Ion Homeostasis Trans-Golgi Network Transport Vesicle Zymogen Granule Membrane Vesicle Targeting Copper Ion Homeostasis Cellular Response To Cadmium Ion Regulation Of Amyloid-beta Clearance Cellular Response To Zinc Ion Cellular Response To Copper Ion COPII Vesicle Coating Phosphatidylinositol-3,4-bisphosphate Binding Embryonic Placenta Development Protein Transmembrane Transporter Activity Protein Localization To Golgi Apparatus Intracellular Zinc Ion Homeostasis Vesicle Cargo Loading Response To Copper Ion Membrane Organization Intermembrane Lipid Transfer Vesicle Budding From Membrane Vesicle Coating Ubiquitin Conjugating Enzyme Binding COPII-coated ER To Golgi Transport Vesicle Response To Cadmium Ion Natural Killer Cell Mediated Cytotoxicity Placenta Development Vitamin Transport Regulation Of Amyloid-beta Formation Natural Killer Cell Mediated Immunity Response To Zinc Ion Cis-Golgi Network	COPI-coated Vesicle Membrane COPI Vesicle Coat Golgi Membrane Transport Vesicle COPI-coated Vesicle Intra-Golgi Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Membrane Coat Endoplasmic Reticulum Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intracellular Transport Intracellular Protein Transport Golgi Apparatus Cytoplasmic Vesicle Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Establishment Of Protein Localization Protein Transport Gamma-secretase Complex Structural Molecule Activity Notch Receptor Processing Amyloid-beta Formation Intracellular Protein Localization Membrane Protein Intracellular Domain Proteolysis Golgi Localization Amyloid Precursor Protein Catabolic Process Endopeptidase Activator Activity Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Membrane Membrane Protein Proteolysis Notch Signaling Pathway Establishment Of Golgi Localization Endoplasmic Reticulum Golgi Cisterna Membrane Protein Localization To Axon Organelle Transport Along Microtubule Embryonic Placenta Development Protein Secretion Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Presynaptic Membrane Vesicle Cargo Loading Dendritic Spine Organization Mitotic Cleavage Furrow Ingression RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
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