WDR81

Description		WD repeat domain 81
Image		No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane
	Molecular Function	Protein Binding Phosphatidylinositol 3-kinase Regulator Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Mitochondrion Organization Aggrephagy Early Endosome To Late Endosome Transport Protein Stabilization
Pathways		CDC42 GTPase cycle
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Calcium levels ( 20705733 24068962) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum albumin levels ( 23022100) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549) Urinary albumin-to-creatinine ratio ( 31630189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		2 interacting genes: MAP1LC3C SQSTM1
Entrez ID		124997
HPRD ID		08748
Ensembl ID		ENSG00000167716
Uniprot IDs		Q24JR4 Q562E7
PDB IDs
Enriched GO Terms of Interacting Partners?		Aggrephagy Mitophagy Autophagosome Autophagy Of Mitochondrion Macroautophagy Autophagy Brown Fat Cell Proliferation Amphisome Ubiquitin Protein Ligase Binding Lewy Body Response To Mitochondrial Depolarisation Fat Cell Proliferation Protein Localization To Perinuclear Region Of Cytoplasm Intracellular Membraneless Organelle Intracellular Protein Transport Ubiquitin-modified Protein Reader Activity Cellular Response To Nitrogen Starvation Regulation Of Protein Complex Stability Negative Regulation Of Ferroptosis Protein Targeting To Vacuole Involved In Autophagy Autolysosome Molecular Sequestering Activity Regulation Of Ferroptosis Pexophagy Organelle Assembly Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylethanolamine Binding Inclusion Body Cytoplasmic Vesicle Positive Regulation Of Long-term Synaptic Potentiation K63-linked Polyubiquitin Modification-dependent Protein Binding Phagophore Assembly Site Ionotropic Glutamate Receptor Binding Protein Exit From Endoplasmic Reticulum Regulation Of Toll-like Receptor 4 Signaling Pathway Protein Transport Aggresome Temperature Homeostasis Regulation Of Long-term Synaptic Potentiation Cell Surface Toll-like Receptor Signaling Pathway SH2 Domain Binding Establishment Of Protein Localization Protein Kinase C Binding Sperm Midpiece Regulation Of Ras Protein Signal Transduction Toll-like Receptor 4 Signaling Pathway Molecular Condensate Scaffold Activity Intracellular Transport Protein Sequestering Activity Organelle Membrane
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