TMEM51 and SEC61G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM51	SEC61G
Description		transmembrane protein 51	SEC61 translocon subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Ssh1 Translocon Complex
	Molecular Function	Protein Binding	Protein Binding Protein Transmembrane Transporter Activity Ribosome Binding
	Biological Process		Protein Targeting Intracellular Protein Transport Protein Transport Post-translational Protein Targeting To Membrane, Translocation Protein Targeting To ER
Pathways			ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Acute ischemic stroke x type 2 diabetes interaction ( 32541925) Cocaine use disorder ( 31490055) Cocaine use disorder x non-traditional parental care interaction ( 31490055)	Metabolite levels ( 23823483) Systemic lupus erythematosus ( 24871463) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		38 interacting genes: AQP6 ARLN BCL2L13 C14orf180 CCDC167 CCL4L2 CLCA4 CREB3 CYB5R3 CYP4F2 EBP GET3 ITCH LMNA MRPL12 NEDD4 NINJ2 PLP2 PTPN5 REEP4 RTP2 SEC61G SFT2D2 SFXN3 SMAGP SMIM1 STRIT1 TMEM107 TMEM14A TMEM14B TMEM242 TMEM254 TMIE TMX2 TSNARE1 UBE2J1 VAMP4 VTI1B	10 interacting genes: AQP6 CREB3 CREB3L1 FAM209A LCN2 LRRC25 PEX12 SEC61A1 SFTPC TMEM51
Entrez ID		55092	23480
HPRD ID		07651	15318
Ensembl ID		ENSG00000171729	ENSG00000132432
Uniprot IDs		Q9BSA0 Q9NW97	P60059
PDB IDs			6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3 8OJ0 8OJ8
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Mitochondrial Membrane Presynaptic Endosome Membrane Endoplasmic Reticulum SNARE Complex	Intracellular Protein Transmembrane Transport Protein Transmembrane Transporter Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Hippocampal Neuron Apoptotic Process Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Protein Transmembrane Transport Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Deacetylase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Pronephric Nephron Development Regulation Of Response To Endoplasmic Reticulum Stress Siderophore Transport Cellular Response To Reactive Oxygen Species Peroxisomal Importomer Complex Extracellular Matrix Constituent Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Cytoplasmic Vesicle Lumen Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Endoplasmic Reticulum Membrane Signal Sequence Binding Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Response To Herbicide Regulation Of Hippocampal Neuron Apoptotic Process Response To Mycotoxin Release From Viral Latency Regulation Of Iron Ion Transport Response To Blue Light Protein Import Into Peroxisome Matrix, Substrate Release Multivesicular Body Lumen Alveolar Lamellar Body CCR1 Chemokine Receptor Binding Sec61 Translocon Complex Response To Reactive Oxygen Species Response To Iron(II) Ion Regulation Of Endothelial Tube Morphogenesis Lamellar Body Monoatomic Anion Channel Activity Renal Water Transport SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation
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