MRE11 and MLF2

Data Source: HiPPIP (Novel)

		MRE11	MLF2
Name		MRE11 double strand break repair nuclease	myeloid leukemia factor 2
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol PML Body Mre11 Complex Site Of Double-strand Break BRCA1-C Complex Chromosomal Region	Nucleus Cytoplasm Membrane Synapse Glutamatergic Synapse
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity Manganese Ion Binding Identical Protein Binding Cadherin Binding	Protein Binding
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Signaling Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Cell Population Proliferation Mitotic Intra-S DNA Damage Checkpoint Signaling Telomeric 3' Overhang Formation Positive Regulation Of Telomere Maintenance Homologous Recombination Meiotic DNA Double-strand Break Formation Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Chromosome Organization Meiotic Cell Cycle R-loop Processing Mitochondrial Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Regulation Of DNA-templated Transcription
Pathways		Cytosolic sensors of pathogen-associated DNA DNA Damage/Telomere Stress Induced Senescence IRF3-mediated induction of type I IFN HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	None
Diseases		Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome	None
GWAS		No GWAS studies recorded	Bitter alcoholic beverage consumption ( 31046077 ) HDL cholesterol levels ( 32203549 )
Novel Interactors		8 novel interactors: - CXCR5 DYNC1H1 ENDOD1 GPR83 JRKL MLF2 TMEM126A	1 novel interactors: MRE11
Interacting Genes		27 interacting genes: ATM ATR CCNE1 CDK2 CDX2 CEBPA DCLRE1C DYNLL1 EP300 FANCD2 GRB2 H1-2 H2AX H4C1 LIG1 LOX MAPK8IP2 NBN NEK1 NKX3-1 PRKDC RAD50 RECQL5 SPOP SUMO1 SUMO2 XRCC6	6 interacting genes: AKT1 HSPB2 P4HA1 SCGN TP53 USP7
Entrez ID		4361	8079
HPRD ID		02889	03238
Ensembl ID		ENSG00000020922	ENSG00000089693
Uniprot IDs		F8W7U8 P49959 Q05D78	A8K1F4 Q15773 Q5U0N1
PDB IDs		3T1I 7ZQY 8BAH 8K00	Not available
GO Terms Enriched among Interactors		DNA Damage Response Telomere Organization DNA Metabolic Process Telomere Maintenance Chromosome Organization DNA Repair Double-strand Break Repair DNA Strand Resection Involved In Replication Fork Processing Chromosome, Telomeric Region Cellular Response To Stress Response To Ionizing Radiation Signal Transduction In Response To DNA Damage DNA Recombination DNA Damage Checkpoint Signaling Protein Localization To Chromosome Histone H2AXS139 Kinase Activity Organelle Organization Negative Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process Recombinational Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of Double-strand Break Repair Negative Regulation Of Cell Cycle Somatic Cell DNA Recombination Regulation Of DNA Metabolic Process V(D)J Recombination Negative Regulation Of Cell Cycle Process Chromosome Response To Gamma Radiation Regulation Of Cell Cycle Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cell Cycle Process Response To Radiation Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break Damaged DNA Binding Mitotic DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Response To Stress Mitotic DNA Integrity Checkpoint Signaling Regulation Of DNA Recombination Regulation Of DNA Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Capping Nonhomologous End Joining Complex Chromatin Remodeling Regulation Of Mitotic Cell Cycle	Regulation Of Glucose Metabolic Process Negative Regulation Of Autophagy Negative Regulation Of Small Molecule Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Telomere Maintenance PML Body Regulation Of DNA Metabolic Process Negative Regulation Of Proteolysis T Cell Apoptotic Process Replication Fork 14-3-3 Protein Binding Lymphocyte Apoptotic Process ER-nucleus Signaling Pathway Negative Regulation Of Macroautophagy Regulation Of Chromosome Organization Cellular Response To Nutrient Levels Regulation Of Release Of Cytochrome C From Mitochondria Leukocyte Apoptotic Process Negative Regulation Of Apoptotic Process Nucleotide-excision Repair Regulation Of Small Molecule Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of TORC1 Signaling Regulation Of Proteolysis Apoptotic Mitochondrial Changes Negative Regulation Of Catabolic Process Regulation Of Autophagy Regulation Of TRNA Methylation TORC1 Signaling Mitotic DNA Integrity Checkpoint Signaling Mitotic DNA Damage Checkpoint Signaling Mitochondrial Double-strand Break Repair Via Homologous Recombination P53 Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition TOR Signaling Response To Heat Regulation Of Cell Cycle Phase Transition Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of Organelle Organization Site Of Double-strand Break DNA Damage Checkpoint Signaling Positive Regulation Of Protein Localization To Endoplasmic Reticulum Import Into Nucleus Response To Nutrient Levels Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Positive Regulation Of Organelle Organization