MLF2 and P4HA1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		MLF2	P4HA1
Description		myeloid leukemia factor 2	prolyl 4-hydroxylase subunit alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Synapse Glutamatergic Synapse	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Procollagen-proline 4-dioxygenase Complex
	Molecular Function	Protein Binding	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Identical Protein Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Regulation Of DNA-templated Transcription	Collagen Fibril Organization
Pathways			Collagen biosynthesis and modifying enzymes
Drugs			Ascorbic acid Proline Hydralazine
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) HDL cholesterol levels ( 32203549)	Alanine aminotransferase levels ( 33547301)
Interacting Genes		6 interacting genes: AKT1 HSPB2 P4HA1 SCGN TP53 USP7	3 interacting genes: MLF2 OGT SUMO2
Entrez ID		8079	5033
HPRD ID		03238	08901
Ensembl ID		ENSG00000089693	ENSG00000122884
Uniprot IDs		A8K1F4 Q15773 Q5U0N1	P13674 Q5VSQ6
PDB IDs			1TJC 2V5F 2YQ8 4BT8 4BT9 4BTA 4BTB
Enriched GO Terms of Interacting Partners?		Regulation Of Glucose Metabolic Process Negative Regulation Of Autophagy Negative Regulation Of Small Molecule Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Telomere Maintenance PML Body Regulation Of DNA Metabolic Process Negative Regulation Of Proteolysis T Cell Apoptotic Process Replication Fork 14-3-3 Protein Binding Lymphocyte Apoptotic Process ER-nucleus Signaling Pathway Negative Regulation Of Macroautophagy Regulation Of Chromosome Organization Cellular Response To Nutrient Levels Regulation Of Release Of Cytochrome C From Mitochondria Leukocyte Apoptotic Process Negative Regulation Of Apoptotic Process Nucleotide-excision Repair Regulation Of Small Molecule Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of TORC1 Signaling Regulation Of Proteolysis Apoptotic Mitochondrial Changes Negative Regulation Of Catabolic Process Regulation Of Autophagy Regulation Of TRNA Methylation TORC1 Signaling Mitotic DNA Integrity Checkpoint Signaling Mitotic DNA Damage Checkpoint Signaling Mitochondrial Double-strand Break Repair Via Homologous Recombination P53 Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition TOR Signaling Response To Heat Regulation Of Cell Cycle Phase Transition Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of Organelle Organization Site Of Double-strand Break DNA Damage Checkpoint Signaling Positive Regulation Of Protein Localization To Endoplasmic Reticulum Import Into Nucleus Response To Nutrient Levels Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Positive Regulation Of Organelle Organization	Glutamatergic Synapse Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Carbon Catabolite Regulation Of Transcription Regulation Of Transcription By Glucose NSL Complex Regulation Of Proteolysis Regulation Of Protein Catabolic Process
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