ATXN2L and MIR128-1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		ATXN2L	MIR128-1
Description		ataxin 2 like	microRNA 128-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Nuclear Speck	Extracellular Space RISC Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Cadherin Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	MRNA Metabolic Process Stress Granule Assembly	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Negative Regulation Of Lipoprotein Particle Clearance Negative Regulation Of Cell Migration MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Cholesterol Homeostasis Positive Regulation Of Cell Adhesion Lipid Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Cholesterol Efflux Negative Regulation Of Lipoprotein Transport Negative Regulation Of Macrophage Colony-stimulating Factor Production Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Macrophage Migration
Pathways
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29679657) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 20935630 28448500 28552196) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Crohn's disease ( 28067908) Educational attainment ( 23722424 25201988) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Extremely high intelligence ( 29520040) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Left-handedness ( 32989287) Pediatric autoimmune diseases ( 26301688) Waist circumference ( 28552196) Weight ( 28552196)	Body mass index ( 26426971)
Interacting Genes		42 interacting genes: ATXN1 BOLL CEBPA EPOR HADHA HOXA1 KRTAP12-4 MIR1-1 MIR10B MIR128-1 MIR128-2 MIR15B MIR16-2 MIR17 MIR19A MIR200C MIR205 MIR20B MIR21 MIR214 MIR25 MIR31 MIR34A MIR34B MIR363 MIR7-1 MIR7-2 MIR7-3 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MPL OGT	91 interacting genes: AIMP1 AIMP2 APOBEC3B ATXN2 ATXN2L C1QBP CASC3 CELF1 CPSF6 CRTAP DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC LSM10 LSM11 MARS1 MATR3 MSI2 NOL6 NONO NUDT16L1 NUFIP2 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PUF60 PURA PURB QARS1 RARS1 RBFOX2 RBM10 RBM12B RBM14 RBM17 RBM4 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SYNCRIP TAF15 TENT2 TRA2A TRA2B U2SURP UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZFR
Entrez ID		11273	406915
HPRD ID		06394
Ensembl ID		ENSG00000168488	ENSG00000207654
Uniprot IDs		H3BUF6 Q8WWM7
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA Destabilization Negative Regulation Of Translation RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Cell Migration Regulation Of Translation Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Space Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Proliferation Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Connective Tissue Replacement Negative Regulation Of Signal Transduction	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Post-transcriptional Regulation Of Gene Expression Nucleus Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule Nucleoplasm Spliceosomal Complex Regulation Of Translation Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Primary Metabolic Process MRNA 3'-UTR Binding Regulation Of Macromolecule Metabolic Process MiRNA Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization MRNA Stabilization Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Stability Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression RNA Transport TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of MRNA Stability TRNA Aminoacylation Nucleolus Negative Regulation Of Gene Expression
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