ACKR5 and ABHD12

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ACKR5	ABHD12
Description		atypical chemokine receptor 5	abhydrolase domain containing 12, lysophospholipase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane AMPA Glutamate Receptor Complex Dendrite Cytoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity Monoacylglycerol Lipase Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway	Lipid Metabolic Process Phosphatidylserine Catabolic Process Adult Walking Behavior Phospholipid Catabolic Process Response To Auditory Stimulus Arachidonate Metabolic Process Acylglycerol Catabolic Process Glycerophospholipid Catabolic Process Regulation Of Inflammatory Response Monoacylglycerol Catabolic Process Macromolecule Depalmitoylation
Pathways			Arachidonate production from DAG
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Serum alkaline phosphatase levels ( 31666285 33547301)
Interacting Genes		10 interacting genes: ABHD12 GOSR1 HLA-C ITGA5 MPG OGFR PLPPR3 TMEM101 TMEM30A TMUB2	2 interacting genes: ACKR5 DYRK1A
Entrez ID		11318	26090
HPRD ID		05605	07094
Ensembl ID		ENSG00000166856	ENSG00000100997
Uniprot IDs		O15218	A0A5F9ZH71 Q8N2K0
PDB IDs
Enriched GO Terms of Interacting Partners?			Histone H3T45 Kinase Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Neurofilament Splicing Factor Binding Regulation Of Heterochromatin Formation Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Tau-protein Kinase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Chromatin Organization Regulation Of Inclusion Body Assembly Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of RNA Splicing Positive Regulation Of RNA Splicing Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Amyloid-beta Formation Negative Regulation Of Microtubule Polymerization Or Depolymerization Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Signal Transduction By P53 Class Mediator Tau Protein Binding Regulation Of Amyloid Precursor Protein Catabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Microtubule Polymerization Tubulin Binding Cytoskeletal Protein Binding Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Amide Metabolic Process Actin Filament
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