MOCS2 and ABCF3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		MOCS2	ABCF3
Gene Name		molybdenum cofactor synthesis 2	ATP-binding cassette, sub-family F (GCN20), member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Molybdopterin Synthase Complex Extracellular Vesicular Exosome	Membrane
	Molecular Function	Nucleotide Binding Molybdopterin Synthase Activity Identical Protein Binding	ATP Binding ATPase Activity
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Biosynthetic Process Small Molecule Metabolic Process	Metabolic Process Defense Response To Virus
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Molybdenum cofactor biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Molybdenum cofactor biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS			Major depressive disorder ( 22472876)
Protein-Protein Interactions		3 interactors: ABCF3 MOCS3 RPL9	14 interactors: ACIN1 CCDC33 DLEU1 DNALI1 FCHSD2 HIRIP3 LAMTOR1 MOCS2 NOA1 SLC35E1 SPP1 TBPL1 TOE1 TRIM27
Entrez ID		4338	55324
HPRD ID		04750	12404
Ensembl ID		ENSG00000164172	ENSG00000161204
Uniprot IDs		O96007 O96033	Q9NUQ8
PDB IDs		4AP8
Enriched GO Terms of Interacting Partners?		TRNA Wobble Position Uridine Thiolation Enzyme Active Site Formation Via L-cysteine Persulfide Protein Adenylylation Protein Urmylation TRNA Thio-modification TRNA Wobble Uridine Modification Molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process	Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Reproduction Organelle Organization Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of Interleukin-2 Secretion Single Organism Reproductive Process Endosome Localization Regulation Of Cholesterol Import Reproductive Process DTTP Biosynthetic Process Apoptotic Chromosome Condensation Negative Regulation Of Calcium Ion Import Positive Regulation Of Monocyte Differentiation Negative Regulation Of Collateral Sprouting
Tagcloud ?		1136a 667inscga aldehyde brazilian catabolism cofactor confirmation deficiencies deterioration detoxification encephalopathy geph homocysteine inborn mocs1 mocs3 molybdenum obtaining oxidase radiologic resembling specialized sulfite sulfur suox tentative turkish uric xanthine
Tagcloud (Difference) ?		1136a 667inscga aldehyde brazilian catabolism cofactor confirmation deficiencies deterioration detoxification encephalopathy geph homocysteine inborn mocs1 mocs3 molybdenum obtaining oxidase radiologic resembling specialized sulfite sulfur suox tentative turkish uric xanthine
Tagcloud (Intersection) ?