MOCS2

Name	molybdenum cofactor synthesis 2
Structure
Interactors	5 interactors: ABCF3 KRAS MOCS3 RPL9 STK11
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Nuclear Speck Molybdopterin Synthase Complex
	Molecular Function	Nucleotide Binding Protein Binding Transferase Activity Molybdopterin Synthase Activity
	Biological Process	Mo-molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Biosynthetic Process
Pathways	Molybdenum cofactor biosynthesis Molybdenum cofactor biosynthesis
Drugs	Fosdenopterin
Diseases	Xanthinuria
GWAS	Acne (severe) ( 24927181 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Corneal hysteresis ( 32716492 ) Intraocular pressure ( 29235454 ) Keratoconus ( 33649486 ) Systemic juvenile idiopathic arthritis ( 27927641 )
Entrez ID	4338
HPRD ID	04750
Ensembl ID	ENSG00000164172
Uniprot IDs	O96007 O96033
PDB IDs	4AP8 5MPO
GO Terms Enriched among Interactors ?	LRR Domain Binding Adenylyltransferase Activity Molybdopterin-synthase Adenylyltransferase Activity URM1 Activating Enzyme Activity Molybdopterin-synthase Sulfurtransferase Activity Nucleotide Binding Anatomical Structure Homeostasis Tissue Homeostasis Response To Isolation Stress GMP Binding Forebrain Astrocyte Development Intracellular Protein-containing Complex Positive Regulation Of Vesicle Transport Along Microtubule Molybdopterin Cofactor Metabolic Process TRNA Thio-modification TRNA Wobble Position Uridine Thiolation Protein Urmylation Mo-molybdopterin Cofactor Biosynthetic Process Thiosulfate-cyanide Sulfurtransferase Activity Molybdopterin Cofactor Biosynthetic Process Positive Regulation Of Neurogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Sulfurtransferase Activity Response To Gravity Type I Pneumocyte Differentiation Positive Regulation Of Nervous System Development Regulation Of Organelle Transport Along Microtubule Epithelial Cell Proliferation Involved In Prostate Gland Development Dendrite Extension Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Ubiquitin-like Modifier Activating Enzyme Activity Myoblast Proliferation Response To Light Stimulus Positive Thymic T Cell Selection Anoikis Regulation Of Neurogenesis Positive T Cell Selection Cellular Response To UV-B Golgi Localization G1 To G0 Transition TRNA Wobble Uridine Modification Positive Regulation Of Cellular Senescence ATP Binding Positive Regulation Of Rac Protein Signal Transduction Astrocyte Development Positive Regulation Of Cell Development Focal Adhesion Response To Radiation Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Nervous System Development