MOCS2 and MOCS3

Number of citations of the paper that reports this interaction (PMID 15073332)
21

Data Source:
HPRD (in vivo)

		MOCS2	MOCS3
Gene Name		molybdenum cofactor synthesis 2	molybdenum cofactor synthesis 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Molybdopterin Synthase Complex Extracellular Vesicular Exosome	Cytosol
	Molecular Function	Nucleotide Binding Molybdopterin Synthase Activity Identical Protein Binding	Thiosulfate Sulfurtransferase Activity Protein Binding ATP Binding Nucleotidyltransferase Activity Sulfurtransferase Activity URM1 Activating Enzyme Activity Metal Ion Binding Molybdopterin-synthase Sulfurtransferase Activity Molybdopterin-synthase Adenylyltransferase Activity Protein Adenylyltransferase Activity
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Biosynthetic Process Small Molecule Metabolic Process	TRNA Wobble Uridine Modification TRNA Wobble Position Uridine Thiolation Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Protein Adenylylation Enzyme Active Site Formation Via L-cysteine Persulfide Molybdopterin Cofactor Biosynthetic Process Protein Urmylation TRNA Thio-modification Small Molecule Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Molybdenum cofactor biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Molybdenum cofactor biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Molybdenum cofactor biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ABCF3 MOCS3 RPL9	3 interactors: EXOSC6 MOCS2 XRN2
Entrez ID		4338	27304
HPRD ID		04750	10092
Ensembl ID		ENSG00000164172	ENSG00000124217
Uniprot IDs		O96007 O96033	O95396
PDB IDs		4AP8	3I2V
Enriched GO Terms of Interacting Partners?		TRNA Wobble Position Uridine Thiolation Enzyme Active Site Formation Via L-cysteine Persulfide Protein Adenylylation Protein Urmylation TRNA Thio-modification TRNA Wobble Uridine Modification Molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process	RNA Catabolic Process DNA Deamination Aromatic Compound Catabolic Process MRNA Metabolic Process Molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Isotype Switching RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response DNA Metabolic Process B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Immunoglobulin Production Heterocycle Metabolic Process DNA-templated Transcription, Termination Water-soluble Vitamin Metabolic Process DNA Modification Nitrogen Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis Vitamin Metabolic Process RRNA Processing Catabolic Process RRNA Metabolic Process DNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Cell Growth Coenzyme Biosynthetic Process Leukocyte Activation Involved In Immune Response B Cell Activation MRNA Catabolic Process
Tagcloud ?		1136a 667inscga aldehyde brazilian catabolism cofactor confirmation deficiencies deterioration detoxification encephalopathy geph homocysteine inborn mocs1 mocs3 molybdenum obtaining oxidase radiologic resembling specialized sulfite sulfur suox tentative turkish uric xanthine	1136a 667inscga aldehyde brazilian catabolism cofactor confirmation deficiencies deterioration detoxification encephalopathy geph homocysteine inborn mocs1 mocs2 molybdenum obtaining oxidase radiologic resembling specialized sulfite sulfur suox tentative turkish uric xanthine
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		1136a 667inscga aldehyde brazilian catabolism cofactor confirmation deficiencies deterioration detoxification encephalopathy geph homocysteine inborn mocs1 mocs2 mocs3 molybdenum obtaining oxidase radiologic resembling specialized sulfite sulfur suox tentative turkish uric xanthine