MTM1

Name	myotubularin 1
Structure	No pdb structure
Interactors	3 interactors: BTG3 KMT2A MTMR12
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Late Endosome Cytosol Plasma Membrane Membrane Sarcomere Filopodium I Band Cell Projection
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphoprotein Phosphatase Activity Protein Binding Hydrolase Activity Intermediate Filament Binding Phosphatidylinositol Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
	Biological Process	Autophagosome Assembly Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Mitochondrion Organization Endosome To Lysosome Transport Protein Transport TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Vacuole Organization Intermediate Filament Organization Muscle Cell Cellular Homeostasis Phosphatidylinositol Dephosphorylation Mitochondrion Distribution Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Autophagosome Assembly
Pathways	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane
Diseases	Centronuclear myopathy
GWAS	No GWAS studies recorded
Entrez ID	4534
HPRD ID	02331
Ensembl ID	ENSG00000171100
Uniprot IDs	A0A8I5KQR6 A0A8I5KZ76 Q13496
PDB IDs	Not available
GO Terms Enriched among Interactors ?	T-helper 2 Cell Differentiation Unmethylated CpG Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity MLL1/2 Complex Negative Regulation Of Heterochromatin Formation Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Minor Groove Of Adenine-thymine-rich DNA Binding Regulation Of Heterochromatin Formation Histone H3K4 Methyltransferase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Definitive Hemopoiesis Response To Potassium Ion Embryonic Hemopoiesis Regulation Of Chromatin Organization Spleen Development Negative Regulation Of Cell Population Proliferation T-helper Cell Differentiation Histone Methyltransferase Complex MLL1 Complex Exploration Behavior Homeostasis Of Number Of Cells Within A Tissue Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation T Cell Differentiation Involved In Immune Response Positive Regulation Of Gene Expression, Epigenetic Visual Learning Transcription Initiation-coupled Chromatin Remodeling CD4-positive, Alpha-beta T Cell Differentiation Membrane Depolarization Visual Behavior Regulation Of Neuronal Synaptic Plasticity CD4-positive, Alpha-beta T Cell Activation Cellular Response To Transforming Growth Factor Beta Stimulus Sarcomere Circadian Regulation Of Gene Expression Alpha-beta T Cell Differentiation Sarcoplasmic Reticulum T Cell Activation Involved In Immune Response Response To Transforming Growth Factor Beta