MTM1 and MTMR12

Number of citations: 32 (PubMedID 12847286)
Data Source: HPRD (in vitro)

		MTM1	MTMR12
Name		myotubularin 1	myotubularin related protein 12
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Late Endosome Cytosol Plasma Membrane Membrane Sarcomere Filopodium I Band Cell Projection	Cytoplasm Cytosol Membrane Sarcoplasmic Reticulum Sarcomere
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphoprotein Phosphatase Activity Protein Binding Hydrolase Activity Intermediate Filament Binding Phosphatidylinositol Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity	Protein Binding
	Biological Process	Autophagosome Assembly Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Mitochondrion Organization Endosome To Lysosome Transport Protein Transport TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Vacuole Organization Intermediate Filament Organization Muscle Cell Cellular Homeostasis Phosphatidylinositol Dephosphorylation Mitochondrion Distribution Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Autophagosome Assembly	None
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane	Synthesis of PIPs at the early endosome membrane
Diseases		Centronuclear myopathy	None
GWAS		No GWAS studies recorded	Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834 )
Interacting Genes		3 interacting genes: BTG3 KMT2A MTMR12	1 interacting genes: MTM1
Entrez ID		4534	54545
HPRD ID		02331	05933
Ensembl ID		ENSG00000171100	ENSG00000150712
Uniprot IDs		A0A8I5KQR6 A0A8I5KZ76 Q13496	Q9C0I1
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		T-helper 2 Cell Differentiation Unmethylated CpG Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity MLL1/2 Complex Negative Regulation Of Heterochromatin Formation Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Minor Groove Of Adenine-thymine-rich DNA Binding Regulation Of Heterochromatin Formation Histone H3K4 Methyltransferase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Definitive Hemopoiesis Response To Potassium Ion Embryonic Hemopoiesis Regulation Of Chromatin Organization Spleen Development Negative Regulation Of Cell Population Proliferation T-helper Cell Differentiation Histone Methyltransferase Complex MLL1 Complex Exploration Behavior Homeostasis Of Number Of Cells Within A Tissue Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation T Cell Differentiation Involved In Immune Response Positive Regulation Of Gene Expression, Epigenetic Visual Learning Transcription Initiation-coupled Chromatin Remodeling CD4-positive, Alpha-beta T Cell Differentiation Membrane Depolarization Visual Behavior Regulation Of Neuronal Synaptic Plasticity CD4-positive, Alpha-beta T Cell Activation Cellular Response To Transforming Growth Factor Beta Stimulus Sarcomere Circadian Regulation Of Gene Expression Alpha-beta T Cell Differentiation Sarcoplasmic Reticulum T Cell Activation Involved In Immune Response Response To Transforming Growth Factor Beta	Positive Regulation Of Striated Muscle Tissue Development Phosphatidylinositol-3-phosphate Phosphatase Activity Muscle Cell Cellular Homeostasis Negative Regulation Of Autophagosome Assembly Intermediate Filament Binding Positive Regulation Of Skeletal Muscle Tissue Growth Phosphatidylinositol Dephosphorylation Skeletal Muscle Tissue Growth I Band Regulation Of Skeletal Muscle Tissue Development Regulation Of Skeletal Muscle Tissue Growth Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Mitochondrion Distribution Positive Regulation Of Skeletal Muscle Tissue Development Phospholipid Dephosphorylation Regulation Of Autophagosome Assembly Regulation Of Striated Muscle Tissue Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Muscle Organ Development Negative Regulation Of Macroautophagy Sarcomere Endosome To Lysosome Transport Mitochondrion Localization Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Vacuole Organization Intermediate Filament Organization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Filopodium Protein Dephosphorylation Autophagosome Assembly Negative Regulation Of TOR Signaling TOR Signaling Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Negative Regulation Of Autophagy Autophagosome Organization Ruffle Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Binding Lysosomal Transport Negative Regulation Of Protein Catabolic Process Phosphatidylinositol Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Dephosphorylation Phosphoprotein Phosphatase Activity Lipid Modification Negative Regulation Of Proteolysis