MTM1 and MTMR12

Number of citations of the paper that reports this interaction (PMID 12847286)
23

Data Source:
HPRD (in vitro)

		MTM1	MTMR12
Gene Name		myotubularin 1	myotubularin related protein 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Late Endosome Cytosol Plasma Membrane Filopodium I Band Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Intermediate Filament Binding Phosphatidylinositol Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity	Protein Binding Phosphatase Activity
	Biological Process	Protein Dephosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endosome To Lysosome Transport Protein Transport Peptidyl-tyrosine Dephosphorylation Regulation Of Vacuole Organization Small Molecule Metabolic Process Intermediate Filament Organization Muscle Cell Cellular Homeostasis Phosphatidylinositol Dephosphorylation Mitochondrion Distribution Mitochondrion Morphogenesis	Dephosphorylation Toxin Transport
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Metabolism of lipids and lipoproteins Phospholipid metabolism Synthesis of PIPs at the late endosome membrane PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: KMT2A MTMR12	1 interactors: MTM1
Entrez ID		4534	54545
HPRD ID		02331	05933
Ensembl ID		ENSG00000171100	ENSG00000150712
Uniprot IDs		B7Z499 Q13496	Q9C0I1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Response To Drug Regulation Of Histone H3-K14 Acetylation Regulation Of Cellular Response To Drug Regulation Of Response To Drug Regulation Of Histone H3-K9 Acetylation Histone H3-K4 Trimethylation Histone H4-K16 Acetylation Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H3-K4 Methylation Peptidyl-lysine Trimethylation Histone H3-K4 Methylation Embryonic Hemopoiesis Positive Regulation Of Histone Methylation Toxin Transport Regulation Of Histone Acetylation Histone H4 Acetylation Regulation Of Histone Methylation Positive Regulation Of Transporter Activity DNA Methylation Positive Regulation Of Histone Modification Circadian Regulation Of Gene Expression DNA Modification Histone Lysine Methylation Peptidyl-lysine Methylation Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Histone Methylation Internal Protein Amino Acid Acetylation Regulation Of Histone Modification Protein Acetylation	Mitochondrion Distribution Regulation Of Vacuole Organization Intermediate Filament Organization Mitochondrion Morphogenesis Muscle Cell Cellular Homeostasis Phosphatidylinositol Dephosphorylation Endosome To Lysosome Transport Mitochondrion Localization Phospholipid Dephosphorylation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Lysosomal Transport Vacuolar Transport Phosphatidylinositol Biosynthetic Process Peptidyl-tyrosine Dephosphorylation Glycerophospholipid Biosynthetic Process Lipid Modification Endosomal Transport Phosphatidylinositol Metabolic Process Phospholipid Biosynthetic Process Protein Dephosphorylation Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Mitochondrion Organization
Tagcloud ?		adeno atrogenes autophagosomes autophagy balance centronuclear foxo3a hypotrophy igf1 igf1r lc3 machinery muscles myopathy myotubular myotubularin normalized overactivation p62 phases phosphoinositide presymptomatic proteasome rescued supporting symptomatic ubiquitin unbalanced xlmtm
Tagcloud (Difference) ?		adeno atrogenes autophagosomes autophagy balance centronuclear foxo3a hypotrophy igf1 igf1r lc3 machinery muscles myopathy myotubular myotubularin normalized overactivation p62 phases phosphoinositide presymptomatic proteasome rescued supporting symptomatic ubiquitin unbalanced xlmtm
Tagcloud (Intersection) ?