MUC20 and ALDOB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MUC20	ALDOB
Description		mucin 20, cell surface associated	aldolase, fructose-bisphosphate B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Microvillus Membrane Cell Projection	Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Centriolar Satellite Extracellular Exosome
	Molecular Function	Identical Protein Binding	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Lyase Activity Identical Protein Binding ATPase Binding Molecular Adaptor Activity Fructose-1-phosphate Aldolase Activity Fructose Binding
	Biological Process	Hepatocyte Growth Factor Receptor Signaling Pathway	Fructose Metabolic Process Fructose Catabolic Process Gluconeogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Vacuolar Proton-transporting V-type ATPase Complex Assembly Negative Regulation Of Pentose-phosphate Shunt
Pathways		Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family MET activates RAS signaling O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Hereditary fructose intolerance Glycolysis Gluconeogenesis Fructose catabolism
Drugs			1,6-Fructose Diphosphate (Linear Form) sn-glycerol 3-phosphate Dihydroxyacetone phosphate
Diseases			Hereditary fructose intolerance; Fructosemia
GWAS		Estimated glomerular filtration rate ( 31015462) Lung disease severity in cystic fibrosis ( 26417704)	Age-related cataracts ( 25352737) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Serum alkaline phosphatase levels ( 29403010 33339817 33547301)
Interacting Genes		3 interacting genes: ALDOB ELOVL3 MET	22 interacting genes: AGXT2 APP ATP6V1E1 BMPR1A BUB1 CDKN2A CTNNA1 DCC FLCN HIVEP1 HSPA8 MAP2K4 MCC MLH1 MLH3 MUC20 NRAS SMAD4 SRC STK11 TXN2 USP40
Entrez ID		200958	229
HPRD ID		17615	01972
Ensembl ID		ENSG00000176945	ENSG00000136872
Uniprot IDs		A0A0G2JN31 A0A0G2JR26 A0A0G2JSE2 Q8N307	P05062
PDB IDs			1QO5 1XDL 1XDM 8D44
Enriched GO Terms of Interacting Partners?		Vacuolar Proton-transporting V-type ATPase Complex Assembly Fructose Catabolic Process Regulation Of NADP Metabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Fructose-bisphosphate Aldolase Activity Fructose Binding Negative Regulation Of Pentose-phosphate Shunt Fructose 1,6-bisphosphate Metabolic Process Fructose-1-phosphate Aldolase Activity Regulation Of Pentose-phosphate Shunt Proton-transporting V-type ATPase Complex Assembly Hepatocyte Growth Factor Receptor Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Hepatocyte Growth Factor Receptor Signaling Pathway Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Fatty Acid Elongation, Monounsaturated Fatty Acid Small Molecule Biosynthetic Process Fructose Metabolic Process Glyceraldehyde-3-phosphate Metabolic Process Purine-containing Compound Metabolic Process Monocarboxylic Acid Metabolic Process Positive Regulation Of Endothelial Cell Chemotaxis Semaphorin Receptor Activity Endothelial Cell Morphogenesis Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Alpha-linolenic Acid Metabolic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Linoleic Acid Metabolic Process Negative Regulation Of Rho Protein Signal Transduction Molecular Function Activator Activity Long-chain Fatty-acyl-CoA Metabolic Process Pancreas Development Carboxylic Acid Metabolic Process Fatty-acyl-CoA Biosynthetic Process Organic Acid Metabolic Process Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Microtubule Polymerization Epithelial Cell Morphogenesis Very Long-chain Fatty Acid Metabolic Process Establishment Of Skin Barrier Negative Regulation Of Actin Filament Bundle Assembly Skin Epidermis Development Unsaturated Fatty Acid Biosynthetic Process	Regulation Of Protein Localization To Nucleus Apoptotic Signaling Pathway Negative Regulation Of Multicellular Organismal Process Chiasma Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Import Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Homeostatic Process Mismatch Repair Complex Negative Regulation Of Cell Population Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus Mesendoderm Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of Glycolytic Process Signaling Receptor Activator Activity Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Protein Destabilization Negative Regulation Of Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Epithelial Cell Proliferation Cellular Response To Stress Apoptotic Process Regulation Of Growth Regulation Of Carbohydrate Catabolic Process Cytosol Mismatched DNA Binding Regulation Of Protein Stability Regulation Of Protein Localization Regulation Of Cell Population Proliferation Programmed Cell Death Cell Death Regulation Of ATP Metabolic Process Enzyme Binding Regulation Of MiRNA Transcription Negative Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Reproductive Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Cell Differentiation
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