MEST and RNF19B

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MEST	RNF19B
Name		mesoderm specific transcript	ring finger protein 19B
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Extracellular Exosome	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Cytolytic Granule
	Molecular Function	Catalytic Activity Protein Binding Hydrolase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mesoderm Development Regulation Of Lipid Storage Response To Retinoic Acid	Adaptive Immune Response Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Natural Killer Cell Mediated Cytotoxicity Protein Autoubiquitination
Pathways		None	Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 )
Novel Interactors		1 novel interactors: IRF5	None recorded
Interacting Genes		23 interacting genes: APP BAG6 BLOC1S2 C6orf47 CD300C CEP70 CIAO2A CIDEB CMTM3 CRELD2 DBN1 FBXO7 FEZ1 FST GAD2 HGS ING5 KIFAP3 LIME1 MPZL2 RNF19B ZNF205 ZNF579	30 interacting genes: APOL3 ASGR1 CDIPT CLEC1A DHODH FDPS GIMAP5 GOSR2 ICMT MEST MS4A1 NIPAL4 PPP1CC RAP1GDS1 SACM1L SEC22A SEC23A SELENOK SLC30A3 SLC61A1 TAP1 TMEM100 TMEM120B TMEM208 TMEM31 TNF TSPAN2 UBE2D2 UBE2D3 UBE2L3
Entrez ID		4232	127544
HPRD ID		06776	13725
Ensembl ID		ENSG00000106484	ENSG00000116514
Uniprot IDs		A4D1L9 B4DQW6 Q5EB52	Q6ZMZ0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Gamma-tubulin Binding	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Ubiquitin Conjugating Enzyme Activity