RNF19B and APOL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF19B	APOL3
Description		ring finger protein 19B	apolipoprotein L3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Cytolytic Granule	Extracellular Region Cytoplasm Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Lipid Transporter Activity Protein Binding Lipid Binding
	Biological Process	Adaptive Immune Response Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Natural Killer Cell Mediated Cytotoxicity Protein Autoubiquitination	Lipid Transport Inflammatory Response Lipoprotein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Estimated glomerular filtration rate ( 31152163) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Total intracranial volume ( 31530798)
Interacting Genes		30 interacting genes: APOL3 ASGR1 CDIPT CLEC1A DHODH FDPS GIMAP5 GOSR2 ICMT MEST MS4A1 NIPAL4 PPP1CC RAP1GDS1 SACM1L SEC22A SEC23A SELENOK SLC30A3 SLC61A1 TAP1 TMEM100 TMEM120B TMEM208 TMEM31 TNF TSPAN2 UBE2D2 UBE2D3 UBE2L3	33 interacting genes: AQP6 CYB5R3 ELOVL4 FAM209A FATE1 FXYD6-FXYD2 GJA8 GJB1 GJB5 GJC1 GPR152 GPRC5D HAS3 IL7R LHFPL5 LINC00839 LRRC25 MFSD6 NCALD PMP22 RNF19B SGCB SLC10A1 SLC16A2 SLC1A5 SLC35H1 SLC7A14 STX1A TIMMDC1 TMEM167B TMEM237 TMEM52B TNFRSF10D
Entrez ID		127544	80833
HPRD ID		13725	06264
Ensembl ID		ENSG00000116514	ENSG00000128284
Uniprot IDs		Q6ZMZ0	O95236
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Ubiquitin Conjugating Enzyme Activity	Membrane Connexin Complex Gap Junction Channel Activity Gap Junction Transmembrane Transport Amino Acid Transmembrane Transporter Activity Gap Junction Assembly Plasma Membrane Organic Anion Transport Amino Acid Transmembrane Transport
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