MEIS2 and CRBN

Number of citations of the paper that reports this interaction (PMID 25043012)
1

Data Source:
BioGRID (enzymatic study)

		MEIS2	CRBN
Gene Name		Meis homeobox 2	cereblon
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleolus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding	ATP-dependent Peptidase Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Eye Development Transcription From RNA Polymerase II Promoter Response To Mechanical Stimulus Pancreas Development Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor	Protein Ubiquitination Negative Regulation Of Protein Homooligomerization Negative Regulation Of Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Homodimerization Activity
Pathways
Drugs
Diseases
GWAS		Hyperactive-impulsive symptoms ( 18821565) Response to antipsychotic treatment ( 20195266)	Immune response to smallpox vaccine (IL-6) ( 22542470) White matter integrity ( 23218918)
Protein-Protein Interactions		14 interactors: ANXA1 APP ARNT2 C1orf94 CRBN DGCR6 HOXA13 HOXA9 LINC00238 OSGIN1 PBX1 SQSTM1 TRIM25 ZNHIT3	5 interactors: KDM1A MEIS2 PAK7 RBPMS SUV39H1
Entrez ID		4212	51185
HPRD ID		03443	16750
Ensembl ID		ENSG00000134138	ENSG00000113851
Uniprot IDs		B3KPD8 B7Z6F6 O14770	Q96SW2
PDB IDs		3K2A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Embryonic Limb Morphogenesis Regulation Of Cell Cycle Process Gland Development Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Limb Development Response To Estrogen Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Death Regulation Of G2/M Transition Of Mitotic Cell Cycle Developmental Process Regulation Of Cell Cycle G2/M Phase Transition Proximal/distal Pattern Formation Organ Development Regulation Of Transcription, DNA-templated Embryonic Forelimb Morphogenesis Positive Regulation Of Transcription, DNA-templated Reproductive Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Immune System Process Developmental Process Involved In Reproduction Regulation Of RNA Metabolic Process Forelimb Morphogenesis Sex Differentiation Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Neutrophil Clearance Prostate Gland Development Multicellular Organismal Development Positive Regulation Of Gene Expression Regulation Of Cell Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Urogenital System Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Neutrophil Apoptotic Process Synaptic Growth At Neuromuscular Junction	Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway Histone H3-K9 Dimethylation RNA Metabolic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Gene Expression Positive Regulation Of Megakaryocyte Differentiation Histone H3-K9 Trimethylation Cellular Macromolecule Biosynthetic Process Positive Regulation Of Hormone Biosynthetic Process Peptidyl-lysine Dimethylation Macromolecule Biosynthetic Process Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Histone Modification Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Chromatin Silencing At RDNA Granulocyte Differentiation Regulation Of SMAD Protein Import Into Nucleus Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Circadian Rhythm Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Transcription, DNA-templated Histone H3-K9 Methylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of RNA Metabolic Process Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-lysine Trimethylation Nucleobase-containing Compound Metabolic Process
Tagcloud ?		accumulative aldehyde aldh1a1 blots cbfb cxcl6 devastating diras diras3 feel glaucoma homeobox identifiable immunocytochemistry meshwork negatives pitx2 protocols pursued ranking samd5 sirnas statistic sterile subtle tm tms vis	activates amp ampk binds cereblon controlling delayed deletion dephosphorylation desensitized eif2alpha embryonic endoplasmic fibroblast implying inducers lastly mechanistically perk pkr promoting propose reconstitution regulates reticulum reversed stimuli stress unfolded
Tagcloud (Difference) ?		accumulative aldehyde aldh1a1 blots cbfb cxcl6 devastating diras diras3 feel glaucoma homeobox identifiable immunocytochemistry meshwork negatives pitx2 protocols pursued ranking samd5 sirnas statistic sterile subtle tm tms vis	activates amp ampk binds cereblon controlling delayed deletion dephosphorylation desensitized eif2alpha embryonic endoplasmic fibroblast implying inducers lastly mechanistically perk pkr promoting propose reconstitution regulates reticulum reversed stimuli stress unfolded
Tagcloud (Intersection) ?