MEF2D and CARM1

Number of citations of the paper that reports this interaction (PubMedID 19188441)
47

Data Source:
BioGRID (pull down)

		MEF2D	CARM1
Description		myocyte enhancer factor 2D	coactivator associated arginine methyltransferase 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Replication Fork
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Methyltransferase Activity Protein Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H3R17 Methyltransferase Activity Histone Methyltransferase Activity Histone H3R2 Methyltransferase Activity DNA-binding Transcription Factor Binding
	Biological Process	Apoptotic Process Nervous System Development Adult Heart Development Muscle Organ Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process Positive Regulation Of Cell Population Proliferation Methylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase I Response To CAMP Replication Fork Reversal Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Dendrite Development
Pathways		Transcriptional activation of mitochondrial biogenesis Myogenesis NGF-stimulated transcription NGF-stimulated transcription Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2	BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Estrogen-dependent gene expression Cytoprotection by HMOX1 Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		A body shape index ( 34021172) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Medication use (antimigraine preparations) ( 31015401) Migraine ( 23793025 27182965 27322543 22683712) Migraine - clinic-based ( 23793025) Monocyte count ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) TPE interval (resting) ( 32386560) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Psoriasis ( 23143594 25574825) Psoriasis vulgaris ( 26626624)
Interacting Genes		25 interacting genes: AKT1 APP ASCL1 CABIN1 CARM1 CASP7 CDK6 COPS5 DNMT3L EP300 EPIC1 FBXO7 HDAC4 HDAC5 MAPK14 MAPK7 MEF2A MEF2C NFATC2 PRKACA PRMT5 SKP2 SNCA SP1 YWHAQ	34 interacting genes: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 DZIP3 ELAVL1 EP300 FLII FOS GRIP1 H3-3A H3-3B H3C1 KDM1A MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PRMT8 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRCAP TP53 UBE2I
Entrez ID		4209	10498
HPRD ID		02810	09158
Ensembl ID		ENSG00000116604	ENSG00000142453
Uniprot IDs		Q14814	Q86X55
PDB IDs		7X1N 8C84	2Y1W 2Y1X 4IKP 5DWQ 5DX0 5DX1 5DX8 5DXA 5DXJ 5U4X 6ARJ 6ARV 6D2L 6DVR 6IZQ 6S70 6S71 6S74 6S77 6S79 6S7A 6S7B 6S7C 7FAI 7FAJ 7U9I 8G2H 8G2I 8SIG 8SIH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Cytosol Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Activation Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Neuron Apoptotic Process Transcription Cis-regulatory Region Binding Cellular Response To Fluid Shear Stress Cellular Response To Metal Ion Intracellular Signaling Cassette Cellular Developmental Process Cellular Response To Oxygen-containing Compound DNA-binding Transcription Factor Binding Regulation Of Apoptotic Process Response To Growth Factor RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of Signal Transduction Positive Regulation Of Gene Expression	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Metabolic Process Chromatin Organization Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Binding P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Transcription Coactivator Activity Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Cell Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Epigenetic Regulation Of Gene Expression Enzyme Binding Muscle Cell Differentiation Positive Regulation Of Cell Differentiation RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Developmental Process Nuclear Androgen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Regulation Of Cell Development
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