SOX18 and GKAP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SOX18	GKAP1
Description		SRY-box transcription factor 18	G kinase anchoring protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Golgi Apparatus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Blood Vessel Development Vasculogenesis In Utero Embryonic Development Hair Follicle Development Vasculature Development Lymph Vessel Development Lymphangiogenesis Heart Looping Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Heart Development Tissue Development Hair Cycle Process Embryonic Heart Tube Development Blood Vessel Endothelial Cell Migration Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Anatomical Structure Formation Involved In Morphogenesis Stem Cell Fate Specification Endocardium Formation Lymphatic Endothelial Cell Differentiation Endocardial Cell Differentiation Establishment Of Endothelial Barrier Regulation Of Stem Cell Proliferation	Signal Transduction CGMP-mediated Signaling Positive Regulation Of Insulin Receptor Signaling Pathway
Pathways
Drugs
Diseases		Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Refractive error ( 32231278)	Age at first sexual intercourse ( 34211149) Chronotype ( 30696823) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Triglyceride levels ( 32154731)
Interacting Genes		5 interacting genes: AURKA GKAP1 HMGB1 MECP2 MEF2C	22 interacting genes: AP3B1 C1orf35 DHFR FAM124B FXR2 HDDC3 HGS HSD11B1 KANK2 KAT5 L3MBTL2 MFAP1 NDN PHOSPHO2 PRKG1 RCOR3 SDCBP SH3BP4 SOX18 UBQLN1 UBQLN4 ZCCHC10
Entrez ID		54345	80318
HPRD ID		07208	17042
Ensembl ID		ENSG00000203883	ENSG00000165113
Uniprot IDs		P35713	Q5VSY0
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Development Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Cell Motility Excitatory Postsynaptic Potential Positive Regulation Of Developmental Process Positive Regulation Of Cell Development Animal Organ Development Calcium-dependent Protein Kinase Regulator Activity Regulation Of Cell Differentiation Regulation Of Restriction Endodeoxyribonuclease Activity Regulation Of Apoptotic Process Positive Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Signaling Regulation Of Postsynaptic Membrane Potential Sinoatrial Valve Morphogenesis Chromatin Remodeling Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Apoptotic Cell Clearance Muscle Cell Fate Determination Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Regulation Of Mismatch Repair C-X-C Chemokine Binding Plasma Membrane Bounded Cell Projection Organization Alphav-beta3 Integrin-HMGB1 Complex Chromatin Organization T-helper 1 Cell Activation Epithelial Cell Proliferation Positive Regulation Of Mismatch Repair Positive Regulation Of Lymphocyte Proliferation Plasmacytoid Dendritic Cell Activation Heterochromatin Formation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Cell Development	Protein Localization To Vacuole Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Lysosome Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Targeting Positive Regulation Of Exosomal Secretion Aggrephagy Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Circadian Rhythm Regulation Of Exosomal Secretion Transcription Regulator Complex Epithelium Development Autophagy Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Metabolic Process Respiratory System Process Protein Targeting To Lysosome NADP Binding Response To Methotrexate Cortisol Dehydrogenase (NADP+) Activity 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Interleukin-5 Receptor Complex Vacuolar Transport Macroautophagy Histone H2AK5 Acetyltransferase Activity Regulation Of Autophagy Negative Regulation Of Double-strand Break Repair Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase Activity Negative Regulation Of DNA Repair
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