C10orf55 and DTX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C10orf55	DTX2
Description		chromosome 10 putative open reading frame 55	deltex E3 ubiquitin ligase 2
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Notch Signaling Pathway Protein Ubiquitination
Pathways			Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Multiple sclerosis ( 24076602) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Systemic lupus erythematosus ( 28714469) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		60 interacting genes: ATXN1 BOLA2 BOLA2B CRYBA2 DTX2 FAM168A FAM222B FNDC3B FOXH1 GCA HNF1B HNRNPF HSF4 INCA1 KRTAP15-1 KRTAP6-2 LENG8 LIMS3 LIMS4 MBLAC1 MGAT5B MYOZ3 NRF1 NXF1 OTX1 PFDN5 PITX1 PLEKHB1 PLSCR3 POGZ PRR20A PRR20B PRR20C PRR20D PRR20E RAMAC RBM24 RBM47 RBPMS RBPMS2 ROR2 SAXO4 SMUG1 SNRPB SOHLH1 SOX10 TBX6 TENT5B TENT5D TIAL1 TLE5 TP53BP1 UBAP2 UFSP1 VENTX VEZF1 WWOX YPEL3 ZC3H10 ZNF76	135 interacting genes: ABHD11 ABHD16A ACTMAP ALKBH4 ANAPC11 ANTKMT ARID5A ARMC7 ARNT2 BCL2L11 BICRAL BOLA2-SMG1P6 C10orf55 C1orf94 C22orf39 CCDC57 CFAP68 CIMIP1 CLPP COA6 COQ8A DAZAP2 DOK3 DTX1 DTX3 ECM1 ECSIT EIF4ENIF1 EIF4G1 EYA2 FAM168A FCRL4 FHL2 FHL5 FOXI1 FTO GLYCTK GOLGA2 H3C1 HDC HGS HLX HOXA1 HOXB2 HOXD12 HPCA HPCAL1 HPCAL4 HSFY1 HSFY2 IKZF3 KANK2 KLC3 KLHDC7B KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP6-1 KRTAP7-1 KRTAP8-1 LASP1 LNX1 LRP2BP MBD3L1 MDC1 MED19 MSS51 MVP MXRA8 NCALD NCS1 NHLRC4 NIF3L1 NME4 NOTCH1 OIP5 PARP1 PARP10 PAX5 PLEKHF2 PLEKHG4 PLSCR1 POGZ PRR32 PRR34 PSMB4 QARS1 RBM11 RBPMS RFX6 RHOXF2 RIMBP3 RUNX1 RUNX2 RUNX3 RUSC1 SAXO4 SEC22A SEC23A SEC23B SEPSECS SLC67A1-AS SOHLH1 SPAG8 STX12 SUMO1 TBX15 TEKT5 TENT2 TMEM42 TRIB3 TRIM35 TRIM54 TRIP13 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBQLN4 USP54 VGLL3 VSNL1 ZNF34 ZNF503 ZNF620 ZNF641 ZNF764 ZNF774 ZNF85
Entrez ID		414236	113878
HPRD ID		16580	16841
Ensembl ID		ENSG00000222047	ENSG00000091073
Uniprot IDs			Q86UW9
PDB IDs			6IR0 6Y22 6Y2X 6Y3J
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of RNA Metabolic Process Regulation Of RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA CDS Binding MRNA Stabilization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of MRNA Metabolic Process [2Fe-2S] Cluster Assembly DNA Binding Regulation Of MRNA Splicing, Via Spliceosome Poly(A) RNA Polymerase Activity Iron-sulfur Cluster Assembly Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Nuclear Inclusion Body Pre-mRNA Intronic Binding Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Gene Expression MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Embryonic Digestive Tract Morphogenesis Protein Binding RNA Binding	Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axonemal A Tubule Inner Sheath Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Nucleus Core-binding Factor Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Chromatin Regulation Of Base-excision Repair Broad Specificity Oxidative DNA Demethylase Activity
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