TBC1D3B and BAG3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D3B	BAG3
Description		TBC1 domain family member 3B	BAG cochaperone 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane	Stress Fiber Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Aggresome Z Disc Ciliary Basal Body Protein Folding Chaperone Complex
	Molecular Function	GTPase Activator Activity	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Protein-folding Chaperone Binding Protein Carrier Chaperone
	Biological Process		Autophagosome Assembly Protein Folding Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Striated Muscle Cell Apoptotic Process Negative Regulation Of Striated Muscle Cell Apoptotic Process Spinal Cord Development Cellular Response To Heat Cellular Response To Unfolded Protein Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Muscle Cell Cellular Homeostasis Positive Regulation Of Protein Export From Nucleus Protein Stabilization Chaperone-mediated Autophagy Aggresome Assembly Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Transport Along Microtubule Negative Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Aggrephagy
Pathways			Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Body mass index ( 26426971) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Aspartate aminotransferase levels ( 33547301) Diastolic blood pressure ( 27841878) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Idiopathic dilated cardiomyopathy ( 21459883) Left ventricular ejection fraction ( 32605384 32382064 33495596) Left ventricular end-diastolic volume ( 33495596) Left ventricular end-systolic volume ( 32382064 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Parkinson's disease ( 28892059 27182965 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		9 interacting genes: BAG3 BAG4 GEM GRB2 GTPBP3 HSPB1 MDFI PSMD2 ZRANB1	76 interacting genes: ACD ARRDC3 ATN1 ATXN7L2 BAIAP2L1 BCL2 CRYAB CTDSP1 CYSRT1 CYSTM1 DAZAP2 DNM2 DTX3 DVL1 DVL2 DYNLT1 EGR4 ENTREP1 EYA2 FAM168B FBXO7 FOXD4L1 GGN GLIS3 HELT HSPA1A HSPA5 HSPA8 HSPB2 HSPB2-C11orf52 HSPB7 HSPB8 INCA1 LENG8 LITAF LRRK1 LRRK2 MAGED1 MDFI MRPL38 NEDD8 NIBAN3 NOTO NR1H3 PDE9A PDLIM7 PIH1D2 PLA2G10 PLCG1 PLEKHB1 POT1 PRDM6 PRKAR1B PRR34 PTPN21 RUNX1 SF3B4 SHISA6 SIAH1 SPRY2 SRPK2 TBC1D3B TBC1D3G TINF2 TMEM174 TNK2 TP53BP2 TRIB3 TRIM27 TRIP6 TSC1 UBC UNKL VPS37B WBP2 WNK1
Entrez ID		414059	9531
HPRD ID		11264	04860
Ensembl ID		ENSG00000274808	ENSG00000151929
Uniprot IDs		A6NDS4	O95817
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Transport Along Microtubule Adenyl-nucleotide Exchange Factor Activity Nucleus Protein Folding Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Filament Polymerization Guanyl-nucleotide Exchange Factor Adaptor Activity Negative Regulation Of Protein Kinase C Signaling Proteasome Complex Negative Regulation Of MRNA Modification Positive Regulation Of Protein Polymerization Grb2-EGFR Complex Response To Unfolded Protein Response To Heat Proteasome Storage Granule Autophagosome Assembly TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Protein-folding Chaperone Binding Autophagosome Organization Protein Kinase C Inhibitor Activity Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Z Disc Protein K29-linked Deubiquitination Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Protein Kinase C Signaling Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Aggrephagy Protein K33-linked Deubiquitination Response To Temperature Stimulus Neurotrophin TRKA Receptor Binding Aggresome Assembly Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Supramolecular Fiber Organization Transport Along Microtubule Chaperone-mediated Autophagy Vacuole Organization	Ubiquitin Protein Ligase Binding Protein Refolding Telomere Assembly Regulation Of Protein Stability Shelterin Complex Nuclear Telomere Cap Complex Negative Regulation Of Signal Transduction Protein Folding Chaperone Complex Negative Regulation Of Signaling Negative Regulation Of Cell Communication Identical Protein Binding Telomere Capping Regulation Of Protein Ubiquitination Response To Unfolded Protein Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Primary Metabolic Process Cytoplasm Nucleus Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Metabolic Process Protein Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Intracellular Signal Transduction Protein Folding Chaperone Unfolded Protein Binding WW Domain Binding Convergent Extension Involved In Organogenesis C3HC4-type RING Finger Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Pancreatic Juice Secretion Intracellular Signal Transduction Regulation Of Membrane Permeability Regulation Of Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Component Organization Convergent Extension Involved In Gastrulation ATP-dependent Protein Disaggregase Activity Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Protein Folding Negative Regulation Of DNA Biosynthetic Process Regulation Of Apoptotic Signaling Pathway
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