MAGEA3 and IQSEC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAGEA3	IQSEC1
Description		MAGE family member A3	IQ motif and Sec7 domain ArfGEF 1
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Synaptic Vesicle Postsynaptic Density Membrane Cytoplasmic Vesicle Synapse
	Molecular Function	Protein Binding Histone Deacetylase Binding Caspase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy Negative Regulation Of Protein Processing Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction Positive Regulation Of Keratinocyte Migration Dendritic Spine Development Positive Regulation Of Focal Adhesion Disassembly
Pathways
Drugs
Diseases
GWAS			Body mass index ( 26426971) Motor coordination ( 34177493) Periodontitis (DPAL) ( 24024966) Spondylosis ( 33332786) Systolic blood pressure ( 32902719) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		15 interacting genes: ACOT7 BCL7B CINP DNM1L ENOX2 EXOC5 HLA-DRB1 HTT IQSEC1 KIF27 LSM2 PCYT1A PRKAA1 RUSC1 S100A9	3 interacting genes: APOE MAGEA3 SYT3
Entrez ID		4102	9922
HPRD ID		02166	11052
Ensembl ID		ENSG00000221867	ENSG00000144711
Uniprot IDs		P43357	A0A0C4DGT3 A0A3B3IRZ4 B4DGC5 Q6DN90
PDB IDs		1QEW 4V0P 5BRZ 8T9A 9BD2	3QWM 4C0A 5NLV 5NLY 6FNE 7VMB
Enriched GO Terms of Interacting Partners?		Cell Death Programmed Cell Death Positive Regulation Of Immune Response To Tumor Cell Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphatidylcholine Biosynthetic Process Regulation Of Response To Tumor Cell	Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipoprotein Transport Regulation Of Developmental Growth Negative Regulation Of Dendritic Spine Maintenance Very-low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Very-low-density Lipoprotein Particle Clearance Multivesicular Body, Internal Vesicle Positive Regulation Of Phospholipid Efflux Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Amyloid Fibril Formation AMPA Glutamate Receptor Clustering Lipoprotein Biosynthetic Process NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Triglyceride-rich Lipoprotein Particle Clearance Phosphatidylcholine-sterol O-acyltransferase Activator Activity Positive Regulation Of Dendritic Spine Maintenance Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Plasma Lipoprotein Particle Levels Chylomicron Remnant Clearance Lipoprotein Particle Binding Trans-synaptic Signaling Virion Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Cholesterol Catabolic Process Synaptic Signaling Negative Regulation Of Cholesterol Biosynthetic Process Protein Import High-density Lipoprotein Particle Clearance Regulation Of Proteolysis Negative Regulation Of Cholesterol Metabolic Process Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Dendritic Spine Development
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