MAGEA3 and S100A9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAGEA3	S100A9
Description		MAGE family member A3	S100 calcium binding protein A9
Image
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Secretory Granule Lumen Extracellular Exosome Calprotectin Complex S100A9 Complex
	Molecular Function	Protein Binding Histone Deacetylase Binding Caspase Binding	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Antioxidant Activity Toll-like Receptor 4 Binding Metal Ion Binding Calcium-dependent Protein Binding Arachidonate Binding RAGE Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy Negative Regulation Of Protein Processing Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Immune System Process Leukocyte Migration Involved In Inflammatory Response Chronic Inflammatory Response Autophagy Apoptotic Process Chemotaxis Inflammatory Response Cell-cell Signaling Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Cell Growth Neutrophil Chemotaxis Regulation Of Toll-like Receptor Signaling Pathway Autocrine Signaling Peptidyl-cysteine S-trans-nitrosylation Defense Response To Bacterium Endothelial Cell Migration Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Regulation Of Cytoskeleton Organization Regulation Of Respiratory Burst Involved In Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Aggregation Cellular Oxidant Detoxification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins
Drugs			Calcium Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Asthma ( 31619474) Basophil percentage of white cells ( 32888494) Matrix metalloproteinase-8 levels ( 29212897)
Interacting Genes		15 interacting genes: ACOT7 BCL7B CINP DNM1L ENOX2 EXOC5 HLA-DRB1 HTT IQSEC1 KIF27 LSM2 PCYT1A PRKAA1 RUSC1 S100A9	13 interacting genes: CDC42 EGFR MAGEA1 MAGEA3 MAGEA6 MAPK14 NCF2 PTEN S100A8 S100B SNCA TUBA1A TUBB
Entrez ID		4102	6280
HPRD ID		02166	00472
Ensembl ID		ENSG00000221867	ENSG00000163220
Uniprot IDs		P43357	P06702
PDB IDs		1QEW 4V0P 5BRZ 8T9A 9BD2	1IRJ 1XK4 4GGF 4XJK 5I8N 5W1F 6DS2 7QUV 7UI5 8SJB 8SJC
Enriched GO Terms of Interacting Partners?		Cell Death Programmed Cell Death Positive Regulation Of Immune Response To Tumor Cell Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphatidylcholine Biosynthetic Process Regulation Of Response To Tumor Cell	Regulation Of Synapse Organization Negative Regulation Of Catabolic Process Cell Projection Morphogenesis Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Growth Neuron Projection Morphogenesis Learning Or Memory Forebrain Morphogenesis RAGE Receptor Binding Regulation Of Growth Dendritic Spine Morphogenesis Cellular Developmental Process Cognition Negative Regulation Of Autophagy Regulation Of Signal Transduction Histone Deacetylase Binding Cell Differentiation Regulation Of Autophagy Dentate Gyrus Development Adult Behavior Regulation Of Cellular Component Organization Enzyme Binding Positive Regulation Of Cell Growth Nucleus Regulation Of Peptidyl-serine Phosphorylation Dendritic Spine Organization Response To Lipid Cytosol Regulation Of Cell Communication Regulation Of Signaling Cell Junction Organization Cell Migration Regulation Of Intracellular Signal Transduction Cytoskeleton-dependent Intracellular Transport Apoptotic Process Negative Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of Cell Population Proliferation Neuron Projection Organization Postsynapse Organization Tau Protein Binding Anatomical Structure Morphogenesis Programmed Cell Death Cell Death Extracellular Region Cytoplasm Response To Cytokine Negative Regulation Of Signaling Negative Regulation Of Cell Communication Multivesicular Body, Internal Vesicle Lumen
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