IQSEC1

Description		IQ motif and Sec7 domain ArfGEF 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Synaptic Vesicle Postsynaptic Density Membrane Cytoplasmic Vesicle Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding
	Biological Process	Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction Positive Regulation Of Keratinocyte Migration Dendritic Spine Development Positive Regulation Of Focal Adhesion Disassembly
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Motor coordination ( 34177493) Periodontitis (DPAL) ( 24024966) Spondylosis ( 33332786) Systolic blood pressure ( 32902719) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: APOE MAGEA3 SYT3
Entrez ID		9922
HPRD ID		11052
Ensembl ID		ENSG00000144711
Uniprot IDs		A0A0C4DGT3 A0A3B3IRZ4 B4DGC5 Q6DN90
PDB IDs		3QWM 4C0A 5NLV 5NLY 6FNE 7VMB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipoprotein Transport Regulation Of Developmental Growth Negative Regulation Of Dendritic Spine Maintenance Very-low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Very-low-density Lipoprotein Particle Clearance Multivesicular Body, Internal Vesicle Positive Regulation Of Phospholipid Efflux Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Amyloid Fibril Formation AMPA Glutamate Receptor Clustering Lipoprotein Biosynthetic Process NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Triglyceride-rich Lipoprotein Particle Clearance Phosphatidylcholine-sterol O-acyltransferase Activator Activity Positive Regulation Of Dendritic Spine Maintenance Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Plasma Lipoprotein Particle Levels Chylomicron Remnant Clearance Lipoprotein Particle Binding Trans-synaptic Signaling Virion Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Cholesterol Catabolic Process Synaptic Signaling Negative Regulation Of Cholesterol Biosynthetic Process Protein Import High-density Lipoprotein Particle Clearance Regulation Of Proteolysis Negative Regulation Of Cholesterol Metabolic Process Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Dendritic Spine Development
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