MIR223 and AGO2

Number of citations of the paper that reports this interaction (PubMedID 34381015)
37

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		MIR223	AGO2
Description		microRNA 223	argonaute RISC catalytic component 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Perinuclear Region Of Cytoplasm Extracellular Exosome	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Dendrite Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome RISC-loading Complex Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	MRNA 3'-UTR Binding LncRNA Binding MRNA Base-pairing Post-transcriptional Repressor Activity	RNA 7-methylguanosine Cap Binding RNA Polymerase II Complex Binding Core Promoter Sequence-specific DNA Binding Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism SiRNA Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Endoribonuclease Activity, Cleaving MiRNA-paired MRNA MRNA Cap Binding
	Biological Process	Response To Hypoxia Inflammatory Response Positive Regulation Of Gene Expression Negative Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Rho Protein Signal Transduction MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Defense Response To Bacterium Regulation Of Macrophage Differentiation Positive Regulation Of D-glucose Import Negative Regulation Of Inflammatory Response Negative Regulation Of Necroptotic Process Cellular Response To Lipopolysaccharide Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Pyroptotic Inflammatory Response Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Vasculature Development Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Dendritic Cell Differentiation	Regulation Of DNA-templated Transcription Translation Translational Initiation Regulation Of Translation Post-embryonic Development Gene Expression MiRNA Metabolic Process Positive Regulation Of Gene Expression SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing P-body Assembly Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process RNA Stabilization Positive Regulation Of Translation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RISC Complex Assembly Regulation Of Synapse Maturation SiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Trophoblast Cell Migration
Pathways			Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Nuclear events stimulated by ALK signaling in cancer Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation M-decay: degradation of maternal mRNAs by maternally stored factors Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation
Drugs
Diseases
GWAS			Age-related hearing impairment ( 34108613) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multisite chronic pain ( 33830993) Neurociticism ( 29500382) Type 1 diabetes ( 34012112)
Interacting Genes		1 interacting genes: AGO2	35 interacting genes: AGO1 BTRC DCP1A DCP2 DDX20 DFFA DHX58 DICER1 GEMIN4 HIF1A-AS2 ITCH KAT5 LINC00467 MAPKAPK2 MIR145 MIR19A MIR223 MIR24-1 MIRLET7B MIRLET7I NSD2 PFKP PRKRA PSMC3 RAD51 RBBP6 RNF31 SNCA TARBP2 TBK1 TBKBP1 TRIM55 TRIM63 UBC ZNF415
Entrez ID		407008	27161
HPRD ID			06943
Ensembl ID		ENSG00000284567	ENSG00000123908
Uniprot IDs			Q9UKV8
PDB IDs			3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4F3T 4OLA 4OLB 4W5N 4W5O 4W5Q 4W5R 4W5T 4Z4C 4Z4D 4Z4E 4Z4F 4Z4G 4Z4H 4Z4I 5JS1 5JS2 5KI6 5T7B 5WEA 6CBD 6MDZ 6MFN 6MFR 6N4O 6NIT 6RA4 7C6B 7D7U 7KI3 8D6J 8D71 8THQ 9BEZ 9BF0 9BF2 9CMP
Enriched GO Terms of Interacting Partners?		Endoribonuclease Activity, Cleaving MiRNA-paired MRNA MRNA Cap Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA SiRNA-mediated Gene Silencing By MRNA Destabilization RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism RISC-loading Complex SiRNA Binding Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RISC Complex Assembly SiRNA Processing RNA 7-methylguanosine Cap Binding Negative Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Trophoblast Cell Migration Pre-miRNA Processing Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Amyloid Precursor Protein Biosynthetic Process P-body Assembly Core Promoter Sequence-specific DNA Binding Regulation Of Trophoblast Cell Migration Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MiRNA Metabolic Process MRNA 3'-UTR AU-rich Region Binding Regulation Of Synapse Maturation RNA Polymerase II Complex Binding MiRNA Processing MiRNA Binding RNA Endonuclease Activity MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Translational Initiation Single-stranded RNA Binding Translation Initiation Factor Activity MiRNA-mediated Gene Silencing By Inhibition Of Translation Double-stranded RNA Binding Endonuclease Activity Post-embryonic Development RNA Stabilization Positive Regulation Of Reproductive Process Translational Initiation Cytoplasmic Ribonucleoprotein Granule RISC Complex MRNA Destabilization Negative Regulation Of RNA Catabolic Process P-body RNA Destabilization Regulation Of Translational Initiation Positive Regulation Of MRNA Catabolic Process MiRNA-mediated Post-transcriptional Gene Silencing	RISC Complex Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Catabolic Process Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process RISC-loading Complex MRNA Destabilization RNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Biosynthetic Process RISC Complex Assembly Positive Regulation Of MRNA Catabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Regulation Of MRNA Stability Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of RNA Stability Pre-miRNA Processing Positive Regulation Of MRNA Metabolic Process Response To External Biotic Stimulus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cytokine Production SiRNA Processing Double-stranded RNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Immune Response-activating Signaling Pathway Pre-miRNA Binding MiRNA Processing Regulation Of Defense Response Positive Regulation Of Immune Response Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Pattern Recognition Receptor Signaling Pathway SiRNA Binding Regulation Of Gene Expression Response To Other Organism Immune Response-regulating Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Immune System Process Activation Of Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response Regulation Of Macromolecule Biosynthetic Process Immune System Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?