MIR223

Description		microRNA 223
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	MRNA 3'-UTR Binding LncRNA Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Response To Hypoxia Inflammatory Response Positive Regulation Of Gene Expression Negative Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Rho Protein Signal Transduction MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Defense Response To Bacterium Regulation Of Macrophage Differentiation Positive Regulation Of D-glucose Import Negative Regulation Of Inflammatory Response Negative Regulation Of Necroptotic Process Cellular Response To Lipopolysaccharide Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Pyroptotic Inflammatory Response Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Vasculature Development Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Dendritic Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Interacting Genes		1 interacting genes: AGO2
Entrez ID		407008
HPRD ID
Ensembl ID		ENSG00000284567
Uniprot IDs
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoribonuclease Activity, Cleaving MiRNA-paired MRNA MRNA Cap Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA SiRNA-mediated Gene Silencing By MRNA Destabilization RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism RISC-loading Complex SiRNA Binding Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RISC Complex Assembly SiRNA Processing RNA 7-methylguanosine Cap Binding Negative Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Trophoblast Cell Migration Pre-miRNA Processing Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Amyloid Precursor Protein Biosynthetic Process P-body Assembly Core Promoter Sequence-specific DNA Binding Regulation Of Trophoblast Cell Migration Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MiRNA Metabolic Process MRNA 3'-UTR AU-rich Region Binding Regulation Of Synapse Maturation RNA Polymerase II Complex Binding MiRNA Processing MiRNA Binding RNA Endonuclease Activity MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Translational Initiation Single-stranded RNA Binding Translation Initiation Factor Activity MiRNA-mediated Gene Silencing By Inhibition Of Translation Double-stranded RNA Binding Endonuclease Activity Post-embryonic Development RNA Stabilization Positive Regulation Of Reproductive Process Translational Initiation Cytoplasmic Ribonucleoprotein Granule RISC Complex MRNA Destabilization Negative Regulation Of RNA Catabolic Process P-body RNA Destabilization Regulation Of Translational Initiation Positive Regulation Of MRNA Catabolic Process MiRNA-mediated Post-transcriptional Gene Silencing
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