LIN28A and MIR200B

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		LIN28A	MIR200B
Description		lin-28 RNA binding posttranscriptional regulator A	microRNA 200b
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule	RISC Complex
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Translation Initiation Factor Binding MiRNA Binding Metal Ion Binding Pre-miRNA Binding Protein-RNA Adaptor Activity Sequence-specific MRNA Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Germ Cell Development MiRNA Metabolic Process MiRNA Catabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Stem Cell Population Maintenance Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing RNA 3'-end Processing Positive Regulation Of TOR Signaling Positive Regulation Of Neuron Differentiation Negative Regulation Of Glial Cell Differentiation Positive Regulation Of Translation Stem Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MiRNA-mediated Gene Silencing Cellular Response To Glucose Stimulus Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Pre-miRNA Processing Positive Regulation Of Cytoplasmic Translation	Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Negative Regulation Of Angiogenesis Negative Regulation Of Toll-like Receptor 4 Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Cycle Negative Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Vascular Wound Healing Negative Regulation Of Interleukin-33 Production Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Caffeine consumption from tea ( 33287642) Glucose homeostasis traits ( 25524916) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)
Interacting Genes		74 interacting genes: MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PTBP1 TRIM28 ZDHHC17 ZNF275	83 interacting genes: ADARB1 APOBEC3B AQR C1QBP CDC5L CRTAP DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PTCD3 PUF60 PUM1 QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SART3 SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346
Entrez ID		79727	406984
HPRD ID		17278
Ensembl ID		ENSG00000131914	ENSG00000207730
Uniprot IDs		Q9H9Z2
PDB IDs		2CQF 2LI8 5UDZ 8OPS 8OPT 8OST
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Migration Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Translation Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Space Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Signal Transduction	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome Ribonucleoprotein Complex Post-transcriptional Regulation Of Gene Expression Nucleus Regulation Of Translation MiRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule Regulation Of Gene Expression MRNA 3'-UTR Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of Metabolic Process Negative Regulation Of MRNA Catabolic Process Regulation Of Primary Metabolic Process RNA Stabilization MRNA Stabilization Nucleolus Negative Regulation Of Translation TRNA Metabolic Process Regulation Of MRNA Stability Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Gene Expression Regulation Of RNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity P-body CRD-mediated MRNA Stabilization TRNA Aminoacylation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?