LIN28A and ZNF275

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LIN28A	ZNF275
Description		lin-28 RNA binding posttranscriptional regulator A	zinc finger protein 275
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule	Nucleus
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Translation Initiation Factor Binding MiRNA Binding Metal Ion Binding Pre-miRNA Binding Protein-RNA Adaptor Activity Sequence-specific MRNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Germ Cell Development MiRNA Metabolic Process MiRNA Catabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Stem Cell Population Maintenance Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing RNA 3'-end Processing Positive Regulation Of TOR Signaling Positive Regulation Of Neuron Differentiation Negative Regulation Of Glial Cell Differentiation Positive Regulation Of Translation Stem Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MiRNA-mediated Gene Silencing Cellular Response To Glucose Stimulus Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Pre-miRNA Processing Positive Regulation Of Cytoplasmic Translation	Regulation Of Transcription By RNA Polymerase II
Pathways		Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Caffeine consumption from tea ( 33287642) Glucose homeostasis traits ( 25524916) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)
Interacting Genes		74 interacting genes: MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PTBP1 TRIM28 ZDHHC17 ZNF275	11 interacting genes: BAHD1 KRTAP10-9 LIN28A RBM10 RNF4 TRAF4 TRIM41 ZNF329 ZNF648 ZNF792 ZNF837
Entrez ID		79727	10838
HPRD ID		17278	19053
Ensembl ID		ENSG00000131914	ENSG00000063587
Uniprot IDs		Q9H9Z2	A6NFS0 Q9NSD4
PDB IDs		2CQF 2LI8 5UDZ 8OPS 8OPT 8OST
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Migration Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Translation Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Space Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Signal Transduction	Zinc Ion Binding Metal Ion Binding Regulation Of Primary Metabolic Process Nucleus Identical Protein Binding MiRNA Binding Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Kinetochore Assembly Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Smooth Muscle Cell Apoptotic Process Negative Regulation Of Pre-miRNA Processing Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Ribosome Biogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein-RNA Adaptor Activity Regulation Of Centromere Complex Assembly Regulation Of Nucleobase-containing Compound Metabolic Process SUMO Polymer Binding Negative Regulation Of Protein Localization To Chromatin Microtubule End Regulation Of Ribosome Biogenesis Vascular Associated Smooth Muscle Cell Proliferation
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