MIRLET7F1 and ERAL1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIRLET7F1	ERAL1
Description		microRNA let-7f-1	Era like 12S mitochondrial rRNA chaperone 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane
	Molecular Function	MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleotide Binding RNA Binding Protein Binding GTP Binding RRNA Binding Ribosomal Small Subunit Binding
	Biological Process	Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of TOR Signaling Negative Regulation Of Interleukin-17 Production MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Apoptotic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta	Ribosomal Small Subunit Assembly Ribosome Biogenesis
Pathways			Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Drugs
Diseases
GWAS			Estimated glomerular filtration rate reduction (30%) ( 30955190) Glycated hemoglobin levels ( 28898252 34059833) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 29403010) Pulse pressure ( 30224653) Red cell distribution width ( 32888494)
Interacting Genes		93 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B ATXN2L C1QBP CELF1 DARS1 DDX1 DDX21 DDX3X DDX3Y DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FAM98B FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PUM1 PUM2 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RBM47 RTCA RTCB SART3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346	48 interacting genes: CEP44 ECT2 EXOSC8 MIR1-1 MIR106A MIR106B MIR107 MIR122 MIR138-1 MIR141 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR199A1 MIR199A2 MIR19A MIR19B1 MIR200A MIR200B MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR29B2 MIR34B MIR451A MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7I SRSF4 SSX2IP
Entrez ID		406888	26284
HPRD ID			08466
Ensembl ID		ENSG00000199072	ENSG00000132591
Uniprot IDs			O75616
PDB IDs			8CSP 8CSQ
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Processing Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Macromolecule Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleus MiRNA Binding Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule RNA Splicing, Via Transesterification Reactions Regulation Of Translation Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Nucleoplasm Ribonucleoprotein Complex Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Stability Spliceosomal Complex Regulation Of MRNA Stability Regulation Of MRNA Processing Catalytic Step 2 Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Regulation Of Macromolecule Metabolic Process MRNA Stabilization Negative Regulation Of RNA Catabolic Process MiRNA Processing Negative Regulation Of Macromolecule Metabolic Process RNA Stabilization Regulation Of Metabolic Process Negative Regulation Of Translation TRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Ligase Activity Regulation Of Alternative MRNA Splicing, Via Spliceosome	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Extracellular Vesicle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Regulation Of MRNA Stability Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Stability Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Migration Negative Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Vasculature Development Negative Regulation Of Cell Motility Regulation Of Translation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Extracellular Space
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