MIRLET7F1 and TUT4

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIRLET7F1	TUT4
Description		microRNA let-7f-1	terminal uridylyl transferase 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Exosome	Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome
	Molecular Function	MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity MiRNA Binding Metal Ion Binding RNA Uridylyltransferase Activity
	Biological Process	Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of TOR Signaling Negative Regulation Of Interleukin-17 Production MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Apoptotic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta	Oocyte Maturation MiRNA Metabolic Process MiRNA Catabolic Process Stem Cell Population Maintenance Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing RNA 3'-end Processing Histone MRNA Catabolic Process Transposable Element Silencing By MRNA Destabilization Polyuridylation-dependent MRNA Catabolic Process
Pathways			Deadenylation of mRNA Zygotic genome activation (ZGA) Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS
Interacting Genes		93 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B ATXN2L C1QBP CELF1 DARS1 DDX1 DDX21 DDX3X DDX3Y DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FAM98B FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PUM1 PUM2 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RBM47 RTCA RTCB SART3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346	13 interacting genes: CPSF7 FXR2 MIR143 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7C MIRLET7D MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I YBX2
Entrez ID		406888	23318
HPRD ID			15700
Ensembl ID		ENSG00000199072	ENSG00000134744
Uniprot IDs			Q5TAX3
PDB IDs			6IW6 8OST
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Processing Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Macromolecule Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleus MiRNA Binding Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule RNA Splicing, Via Transesterification Reactions Regulation Of Translation Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Nucleoplasm Ribonucleoprotein Complex Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Stability Spliceosomal Complex Regulation Of MRNA Stability Regulation Of MRNA Processing Catalytic Step 2 Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Regulation Of Macromolecule Metabolic Process MRNA Stabilization Negative Regulation Of RNA Catabolic Process MiRNA Processing Negative Regulation Of Macromolecule Metabolic Process RNA Stabilization Regulation Of Metabolic Process Negative Regulation Of Translation TRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Ligase Activity Regulation Of Alternative MRNA Splicing, Via Spliceosome	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA Destabilization RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of MRNA Metabolic Process Extracellular Space Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-10 Production Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Translation Regulation Of Endothelial Cell Migration Calcidiol 1-monooxygenase Activity Secalciferol 1-monooxygenase Activity Cellular Response To Amyloid-beta Regulation Of Multicellular Organismal Process Positive Regulation Of Catabolic Process Regulation Of Cell Migration Involved In Sprouting Angiogenesis Response To Amyloid-beta
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