MIRLET7C and TENT2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIRLET7C	TENT2
Description		microRNA let-7c	terminal nucleotidyltransferase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm RISC Complex Extracellular Exosome Extracellular Vesicle	Nucleus Cytoplasm Nuclear RNA-directed RNA Polymerase Complex
	Molecular Function	MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding Poly(A) RNA Polymerase Activity
	Biological Process	Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-8 Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT	Hematopoietic Progenitor Cell Differentiation MRNA Processing Regulation Of Gene Expression RNA 3'-end Processing MRNA 3'-end Processing Histone MRNA Catabolic Process Target-directed MiRNA Degradation Negative Regulation Of MiRNA Catabolic Process
Pathways
Drugs
Diseases
GWAS			Leukocyte telomere length ( 32109421)
Interacting Genes		96 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B ATXN2L C1QBP CHERP CPSF1 CPSF6 DARS1 DDX1 DDX21 DDX3X DHX36 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PLOD1 PTBP1 PTBP3 PUF60 PURA QARS1 RARS1 RBFOX2 RBM12B RBM14 RBM4 RBM4B RBMS2 RTCA RTCB SART3 SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TENT2 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346	30 interacting genes: ANXA2 CADPS CALCOCO2 DTX2 KRTAP6-3 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR141 MIR145 MIR155 MIR15B MIR21 MIR222 MIR29A MIR29C MIR34B MIR363 MIR451A MIR9-1 MIR9-2 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7F2 OGT RBPMS
Entrez ID		406885	167153
HPRD ID			15098
Ensembl ID		ENSG00000199030	ENSG00000164329
Uniprot IDs			D6RAF2 Q6PIY7
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of RNA Splicing Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Nucleus Aminoacyl-tRNA Synthetase Multienzyme Complex Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleoplasm MiRNA Binding Spliceosomal Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Catalytic Step 2 Spliceosome Cytoplasmic Stress Granule Regulation Of Translation Negative Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process MRNA 3'-UTR Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Stability Negative Regulation Of MRNA Catabolic Process RNA Stabilization TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of MRNA Stability TRNA Aminoacylation MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Nucleolus Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation TRNA Metabolic Process RNA 3'-end Processing Paraspeckles	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Extracellular Vesicle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Locomotion Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Protein Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Cell Migration Regulation Of Gene Expression MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of MRNA Catabolic Process Extracellular Space Positive Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Endothelial Cell Proliferation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Negative Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Communication Negative Regulation Of Signaling
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