TENT2 and ANXA2

Number of citations of the paper that reports this interaction (PubMedID 21963895)
32

Data Source:
BioGRID (two hybrid)

		TENT2	ANXA2
Description		terminal nucleotidyltransferase 2	annexin A2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear RNA-directed RNA Polymerase Complex	Cornified Envelope Extracellular Region Basement Membrane Extracellular Space Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Lipid Droplet Cytosol Plasma Membrane Adherens Junction Cell Surface Vesicle Membrane Membrane Basolateral Plasma Membrane Nuclear Matrix Midbody Extracellular Matrix Late Endosome Membrane Vesicle Azurophil Granule Lumen Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Membrane Raft Extracellular Exosome RNA Polymerase II Transcription Regulator Complex Plasma Membrane Protein Complex AnxA2-p11 Complex PCSK9-AnxA2 Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding Poly(A) RNA Polymerase Activity	Phosphatidylserine Binding Protease Binding RNA Binding Phospholipase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phospholipase A2 Inhibitor Activity Identical Protein Binding S100 Protein Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Hematopoietic Progenitor Cell Differentiation MRNA Processing Regulation Of Gene Expression RNA 3'-end Processing MRNA 3'-end Processing Histone MRNA Catabolic Process Target-directed MiRNA Degradation Negative Regulation Of MiRNA Catabolic Process	Angiogenesis Membrane Raft Assembly Positive Regulation Of Receptor Recycling Negative Regulation Of Receptor Internalization Vesicle Budding From Membrane Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Plasminogen Activation Response To Activity Collagen Fibril Organization Lung Development Positive Regulation Of Vesicle Fusion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Osteoclast Development Fibrinolysis MRNA Transcription By RNA Polymerase II Positive Regulation Of Vacuole Organization Positive Regulation Of Exocytosis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Cell-cell Adhesion Epithelial Cell Apoptotic Process Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Plasma Membrane Repair
Pathways			Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Pancreatic Ductal Cells
Drugs			Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol
Diseases
GWAS		Leukocyte telomere length ( 32109421)	Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 25102180)
Interacting Genes		30 interacting genes: ANXA2 CADPS CALCOCO2 DTX2 KRTAP6-3 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR141 MIR145 MIR155 MIR15B MIR21 MIR222 MIR29A MIR29C MIR34B MIR363 MIR451A MIR9-1 MIR9-2 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7F2 OGT RBPMS	51 interacting genes: ACTA1 APOH APP CCDC32 CD99 CDC42 CEACAM1 CTSB CTSS DYSF EIF4ENIF1 FNDC3B FOXP1 GRB2 HMGA1 LGALS13 LINC00941 LINC01554 LYPLA1 MAP3K4 MYOC NOD2 OGDH PHB1 PLA1A PLA2G4A PLAT PLG POT1 PRKCA PRKCB PTEN RPS2 S100A10 S100A4 S100A6 SLC26A4-AS1 SMN1 SNCA SNX17 SOS1 SRC STAT6 TENT2 TERF1 TERT TNC TRPV5 WEE2-AS1 YWHAQ ZBTB4
Entrez ID		167153	302
HPRD ID		15098	01061
Ensembl ID		ENSG00000164329	ENSG00000182718
Uniprot IDs		D6RAF2 Q6PIY7	A0A024R5Z7 H0YL33 P07355
PDB IDs			1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH 5LPU 5LPX 5LQ0 5LQ2 5N7D 5N7F 5N7G 6TWQ 6TWU 6TWX 6TWY 7DTO 7EQ7 7NMI 7P70 7P71 7P72 7P73 7P74 7PC3 7PC4 7PC5 7PC7 7PC8 7PC9 7PCB 7QQL 7QQM 7QQN 7ZVN 7ZVX 8AEL
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Extracellular Vesicle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Locomotion Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Protein Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Cell Migration Regulation Of Gene Expression MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of MRNA Catabolic Process Extracellular Space Positive Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Endothelial Cell Proliferation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Negative Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Communication Negative Regulation Of Signaling	Regulation Of Vesicle-mediated Transport Extracellular Exosome Regulation Of Cell Population Proliferation Enzyme Binding Regulation Of Locomotion Negative Regulation Of Wound Healing Regulation Of Transport Nuclear Telomere Cap Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Migration Positive Regulation Of Metabolic Process Negative Regulation Of Fibrinolysis Leukocyte Activation Regulation Of Cell Motility Positive Regulation Of Immune System Process Histone H3T6 Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Cell Junction Assembly Regulation Of Fibrinolysis Negative Regulation Of Coagulation Regulation Of Cell Activation Positive Regulation Of Organelle Organization Regulation Of Immune Response Cell Activation Regulation Of Cell Adhesion Regulation Of MAPK Cascade Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Immune Response Phosphatidylcholine Lysophospholipase Activity Extracellular Matrix Identical Protein Binding Macrophage Activation Positive Regulation Of Cell Migration Regulation Of Endocytosis Negative Regulation Of Cell-substrate Adhesion Telomere Maintenance Via Telomerase Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Myeloid Leukocyte Activation Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Regulation Of Focal Adhesion Assembly Trans-synaptic Signaling By BDNF Protein Kinase C Signaling
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