TENT2 and MIR122

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		TENT2	MIR122
Description		terminal nucleotidyltransferase 2	microRNA 122
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear RNA-directed RNA Polymerase Complex	Extracellular Space RISC Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding Poly(A) RNA Polymerase Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation MRNA Processing Regulation Of Gene Expression RNA 3'-end Processing MRNA 3'-end Processing Histone MRNA Catabolic Process Target-directed MiRNA Degradation Negative Regulation Of MiRNA Catabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways
Drugs
Diseases
GWAS		Leukocyte telomere length ( 32109421)	Gamma glutamyl transferase levels ( 29403010 33339817) High density lipoprotein cholesterol levels ( 29083408) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		30 interacting genes: ANXA2 CADPS CALCOCO2 DTX2 KRTAP6-3 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR141 MIR145 MIR155 MIR15B MIR21 MIR222 MIR29A MIR29C MIR34B MIR363 MIR451A MIR9-1 MIR9-2 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7F2 OGT RBPMS	70 interacting genes: AIMP1 AIMP2 C1QBP CPSF1 DARS1 DDX1 DDX21 DDX3X DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 NOL6 NONO NUDT16L1 NUDT21 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PURA QARS1 RARS1 RBFOX2 RBM14 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SFPQ STRBP SYNCRIP TAF15 TENT2 TRA2A TRA2B UPF1 UTP20 YBX1 YBX3 ZNF346
Entrez ID		167153	406906
HPRD ID		15098
Ensembl ID		ENSG00000164329	ENSG00000284440
Uniprot IDs		D6RAF2 Q6PIY7
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Extracellular Vesicle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Locomotion Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Protein Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Cell Migration Regulation Of Gene Expression MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of MRNA Catabolic Process Extracellular Space Positive Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Endothelial Cell Proliferation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Negative Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Communication Negative Regulation Of Signaling	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of RNA Splicing Nucleus Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Processing Negative Regulation Of MRNA Catabolic Process Regulation Of Gene Expression MRNA Stabilization Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding MiRNA Binding Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Positive Regulation Of Gene Expression Negative Regulation Of Translation TRNA Aminoacylation CRD-mediated MRNA Stabilization Nucleolus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Stability Negative Regulation Of Metabolic Process Ligase Activity Regulation Of Metabolic Process
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