ADAMTS6

Description		ADAM metallopeptidase with thrombospondin type 1 motif 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Kidney Development Cardiac Septum Development Proteolysis Heart Development Extracellular Matrix Organization Aorta Development Coronary Vasculature Development
Pathways		Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		A body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 29760442) Corneal structure ( 23291589) Corpus callosum anterior volume ( 31530798) Cortical surface area (MOSTest) ( 32665545) Feeling tense ( 29500382) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Inguinal hernia ( 26686553) Intraocular pressure ( 29617998 29785010 30054594) LDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Non-response to bupropion and depression ( 27622933) Osteosarcoma ( 23727862) Schizophrenia ( 23212062) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Novel Interacting Genes		5 novel interacting genes: ARSB CD180 CDK7 ERCC8 PART1
Interacting Genes		1 interacting genes: SNTA1
Entrez ID		11174
HPRD ID		05421
Ensembl ID		ENSG00000049192
Uniprot IDs		Q5IR90 Q9UKP5
PDB IDs
Enriched GO Terms of Interacting Partners?		Colon Epithelial Cell Migration RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Regulation Of Transcription-coupled Nucleotide-excision Repair N-acetylgalactosamine-4-sulfatase Activity Intestinal Epithelial Cell Migration
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